Publication: Desarrollo embriológico de la glándula sublingual
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2018-03-20
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Universidad Complutense de Madrid
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Abstract
Los estudios sobre el desarrollo embriológico de las glándulas salivares mayores han ido enfocados a analizar casi en exclusiva la glándula submandibular. Escasas investigaciones han centrado sus objetivos sobre el desarrollo y origen de la glándula sublingual, considerada una glándula salivar mayor tubuloacinar, de secreción mixta, pero predominio mucoso. En el adulto, está localizada en un plano submucoso por encima del músculo milohioideo que delimita el suelo de la boca. A través de un sistema de doble drenaje, la saliva alcanza la cavidad oral por los múltiples conductos de Walther y por el conducto principal de Bartholin que se abre al conducto de Wharton, de la glándula submandibular. Las dudas surgen a la hora de determinar el lugar exacto de origen y el horario morfogenético de la glándula sublingual en el humano, existiendo discrepancias entre los diferentes autores. Para lograr una aproximación de lo que ocurre en la morfogénesis glandular de los humanos, se han desarrollado unos modelos de estudio en rata y ratón, ya que éstos presentan una anatomía y un desarrollo glandular similar al humano. Estos estudios tienen como objetivo valorar los factores que influyen en la morfogénesis glandular y hacen hincapié en la importancia de la interacción entre el epitelio y el mesénquima subyacente; en los factores mesenquimales que influyen en el inicio, la ramificación y la formación de luz en el interior de los conductos; en los factores de la matriz extracelular y la membrana basal; en la influencia neuronal y más recientemente, en la influencia endotelial...
Studies on the embryological development of the major salivary glands have mainly focused on analyzing the submandibular gland. No important research has focused on the development and origin of the sublingual gland, which is considered a major tubuloacinar salivary gland. In an adult, it is located in a submucosal plane above the mylohyoid muscle. With a double drainage system, saliva reaches the oral cavity through both the multiple Walther’s ducts and the main Bartholin's conduct, which opens into the Wharton's duct of the submandibular gland. Controversial ideas and discrepancies between different authors arise in determining the exact origin and morphogenetic development of the sublingual gland in human embryos. In order to determine the details of what happens in a human major gland morphogenesis, tests in rats and mice have been performed thanks to the similar anatomy and development of these animals. These studies aim to assess the factors that influence gland morphogenesis: - The importance of the interaction between epithelium and the underlying mesenchyme, - The mesenchymal factors that influence the initial stages, branching morphogenesis and creation of light inside the ducts, - The extracellular matrix factors and the basement membrane, - The neuronal influence and the endothelial influence...
Studies on the embryological development of the major salivary glands have mainly focused on analyzing the submandibular gland. No important research has focused on the development and origin of the sublingual gland, which is considered a major tubuloacinar salivary gland. In an adult, it is located in a submucosal plane above the mylohyoid muscle. With a double drainage system, saliva reaches the oral cavity through both the multiple Walther’s ducts and the main Bartholin's conduct, which opens into the Wharton's duct of the submandibular gland. Controversial ideas and discrepancies between different authors arise in determining the exact origin and morphogenetic development of the sublingual gland in human embryos. In order to determine the details of what happens in a human major gland morphogenesis, tests in rats and mice have been performed thanks to the similar anatomy and development of these animals. These studies aim to assess the factors that influence gland morphogenesis: - The importance of the interaction between epithelium and the underlying mesenchyme, - The mesenchymal factors that influence the initial stages, branching morphogenesis and creation of light inside the ducts, - The extracellular matrix factors and the basement membrane, - The neuronal influence and the endothelial influence...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Anatomía y Embriología Humanas, leída el 05/07/2017