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Sastre Ibáñez, Marina and Martínez de la Casa, Jose Maria and Rebolleda Fernández, Gema and Cifuentes Canorea, Pilar and Moreno, María Nieves and Morales Fernández, Laura and Sáenz Francés, Federico and García Feijoo, Julián (2018) Utility of Bruch membrane opening-based optic nerve head parameters in myopic subjects. European Journal of Ophthalmology, 28 (1). pp. 42-46. ISSN 1120-6721
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Official URL: https://doi.org/10.5301/ejo.5001022
Abstract
Purpose: To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia.
Methods: In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software. With GPME, we analyzed the neuroretinal rim (Bruch membrane opening-minimum rim width [BMO-MRW]) and RNFL.
Results: The average age of subjects was 30.2 ± 9.3 years for G0 and 29.9 ± 7.1 years for G1 (p = 0.903). Mean sphere was −0.5 ± 0.3 D (-1.25 to 0 D) G0 and -3.9 ± 0.3 D (-6.00 to -3 D) G1 (p<0.001). The RNFL thickness comparison between G0 and G1 showed a significantly lower thickness in G1 (p = 0.018). The BMO-MRW measurements were similar in both groups (p = 0.331). With the BMO-MRW examination, the number of sectors classified as pathologic per subject in G1 were significantly lower compared to RNFL analysis (p = 0.023).
Conclusions: Ring analysis based on BMO-MRW measurements shows a lower rate of false-positives compared to RNFL thickness when studying healthy moderate myopic eyes and it would be advisable to take this into consideration when analyzing these patients.
Item Type: | Article |
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Additional Information: | Article first published online: November 8, 2017; Issue published: January 1, 2018 |
Uncontrolled Keywords: | Bruch membrane opening, Myopia, Optic nerve head, Optical coherence tomography, Retinal nerve fiber layer |
Subjects: | Medical sciences > Medicine > Diagnostic imaging and Nuclear medicine Medical sciences > Medicine > Ophtalmology Medical sciences > Optics > Optometry Medical sciences > Optics > Imaging systems |
ID Code: | 47386 |
Deposited On: | 04 May 2018 10:09 |
Last Modified: | 04 May 2018 17:55 |
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