Publication: Nanopartículas magneto-plasmódicas para aplicaciones biomédicas
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2018-05-21
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Universidad Complutense de Madrid
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Abstract
En los últimos años el estudio y aplicación de las nanopartículas magneto-plasmónicas ha despertado un enorme interés en la comunidad científica. El uso de este tipo de materiales en aplicaciones biomédicas abre la puerta a un gran número de nuevas técnicas de diagnóstico y tratamiento. Sin embargo existe una carencia de materiales biocompatibles que presenten propiedades magneto-plasmónicas adecuadas. En la presente tesis se abordará en primer lugar la síntesis y caracterización de estructuras magneto-plasmónicas híbridas basadas en nanocilindros de Au, nanopartículas magnéticas de diferentes ferritas y sílice. La síntesis de estas nanoestructuras se realizó desarrollando un nuevo método de hibridación que aprovecha el entrecruzamiento que tiene lugar entre las moléculas de polietilenglicol y el ácido cítrico cuando se incluyen en los procesos de crecimiento de sílice como mecanismo de autoensamblado. Para ello la superficie de los nanocilindros de Au y de las nanopartículas de ferritas fueron recubiertas con polietilenglicol y ácido cítrico respectivamente y sometidas a un proceso de silanización conjunta. La estructura obtenida al final del proceso consiste en una geometría núcleo-satélite con los nanocilindros de Au en el centro y las nanopartículas de ferrita alrededor embebidas en una matriz de sílice. La síntesis individual de los componentes magnético y plasmónico, permitió ajustar individualmente sus propiedades antes de ser hibridizados en una estructura común. Sin embargo, aunque este tipo de nanoestructuras evitan la intercara entre las fases, aparece un cierto grado de interacción que obliga a considerar los posibles cambios en las propiedades magneto-plasmónicas del material resultante...
In the recent years, magneto-plasmonic nanoparticles have attracted increasing attention from the scientific community due to their promising properties and high applicability. Thanks to the development of new synthesis routes, it has been possible to use this kind of nanostructures in different biomedical applications such as dual imaging, combined treatments or biodetection. However, there is still a lack of biocompatible materials with suitable magneto-plasmonic features to translate all these advances to clinical studies. In this thesis, I propose a new sythesis to produce hybrid magneto-plasmonic nanoparticles based on Au nanorods, ferrite nanospheres and silica. The synthesis developed takes advantage of the cross-linking process between polyethilenglycol and citric acid during sol-gel reactions of sylanization, to drive the self-assembly between Au nanorods and ferrite nanospheres. Following such method, it was possible to obtain hybrid nanostructures composed by a Au nanorod in the core and ferrite nanospheres in satellite positions imbibed in a silica matrix. The individual synthesis of the components before hybridization enabled the fine tuning of their magnetic and plasmonic properties. Besides in this geometry there are not common interfaces between Au and ferrite, avoiding a direct interaction between them. However, due to the close proximity of the phases, it was important to study the effect of the short-distance interaction in the magneto-plasmonic properties...
In the recent years, magneto-plasmonic nanoparticles have attracted increasing attention from the scientific community due to their promising properties and high applicability. Thanks to the development of new synthesis routes, it has been possible to use this kind of nanostructures in different biomedical applications such as dual imaging, combined treatments or biodetection. However, there is still a lack of biocompatible materials with suitable magneto-plasmonic features to translate all these advances to clinical studies. In this thesis, I propose a new sythesis to produce hybrid magneto-plasmonic nanoparticles based on Au nanorods, ferrite nanospheres and silica. The synthesis developed takes advantage of the cross-linking process between polyethilenglycol and citric acid during sol-gel reactions of sylanization, to drive the self-assembly between Au nanorods and ferrite nanospheres. Following such method, it was possible to obtain hybrid nanostructures composed by a Au nanorod in the core and ferrite nanospheres in satellite positions imbibed in a silica matrix. The individual synthesis of the components before hybridization enabled the fine tuning of their magnetic and plasmonic properties. Besides in this geometry there are not common interfaces between Au and ferrite, avoiding a direct interaction between them. However, due to the close proximity of the phases, it was important to study the effect of the short-distance interaction in the magneto-plasmonic properties...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Físicas, Departamento de Física de Materiales, leída el 07/11/2017