Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid



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Yanguas Casás, Natalia and Crespo Castrillo, Andrea and Ceballos, María L. de and Chowen, Julie A. and Azcoitia Elías, Iñigo and Arévalo, María Ángeles and García Segura, Luis Miguel (2018) Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid. Glia, 66 (3). pp. 522-537. ISSN 0894-1491, ESSN: 1098-1136

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Sex differences in the incidence, clinical manifestation, disease course, and prognosis of neurological diseases, such as autism spectrum disorders or Alzheimer’s disease, have been reported. Obesity has been postulated as a risk factor for cognitive decline and Alzheimer’s disease and, during pregnancy, increases the risk of autism spectrum disorders in the offspring. Obesity is associated with increased serum and brain levels of free fatty acids, such as palmitic acid, which activate microglial cells triggering a potent inflammatory cascade. In this study, we have determined the effect of palmitic acid in the inflammatory profile, motility, and phagocytosis of primary male and female microglia, both in basal conditions and in the presence of a pro-inflammatory stimulus (interferon-g). Male microglia in vitro showed higher migration than female microglia under basal and stimulated conditions. In contrast, female microglia had higher basal and stimulated phagocytic activity than male microglia. Palmitic acid did not affect basal migration or phagocytosis, but abolished the migration and phagocytic activity of male and female microglia in response to interferon-g. These findings extend previous observations of sex differences in microglia and suggest that palmitic acid impairs the protective responses of these cells.

Item Type:Article
Uncontrolled Keywords:Microglia dysfunction; Neuroinflammation; Senescence; Sex differences
Subjects:Medical sciences > Biology > Cytology
Medical sciences > Biology > Neurosciences
ID Code:47675
Deposited On:23 May 2018 08:47
Last Modified:23 May 2018 10:48

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