The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.



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Gómez-Cerezo, Natividad and Verron, E and Montouillout, V and Fayon, F and Lagadec, P and Bouler, J.M. and Bujoli, B and Arcos Navarrete, Daniel and Vallet Regí, María (2018) The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses. Acta Biomaterialia, 76 . pp. 333-343. ISSN 1742-7061 (In Press)

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Mesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has been
characterized using 29Si, 71Ga and 31P NMR analysis, demonstrating that Ga(III) is efficiently incorporated as both, network former (GaO4 units) and network modifier (GaO6 units). In vitro bioactivity tests evidenced that Ga-containing MBGs retain their capability for nucleation and growth of an apatite-like layer in contact with a simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Finally, in vitro cell culture tests evidenced that Ga incorporation results in a selective effect on osteoblasts and osteoclasts. Indeed, the presence of this element enhances the early differentiation towards osteoblast phenotype while disturbing osteoclastogenesis. Considering these results, Ga-doped MBGs might be proposed as bone substitutes, especially in osteoporosis scenarios.

Item Type:Article
Additional Information:

RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Gallium, Mesoporous bioactive glasses, Osteoblast, Osteoclast, Osteoporosis
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:48536
Deposited On:20 Aug 2018 12:21
Last Modified:01 Jul 2020 23:01

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