Publication: Formulación magistral en pediatría
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2015-06
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Abstract
Los beneficios que nos ofrece la elaboración de medicamentos a través de la formulación magistral son innegables y cada vez más reconocidos. El comienzo de la industria farmacéutica hizo que olvidáramos las ventajas de este arte. No obstante, la “despersonalización” que supone la elaboración a gran escala, hace que sea el paciente quien tenga que adaptarse al medicamento, situación compleja en pediatría. Las características especiales de esta población, así como su vulnerabilidad, nos obligan a recurrir a la formulación magistral, la cual nos permite alcanzar el ideal terapéutico: la individualización del tratamiento. El empleo de esta disciplina se ve acentuado por la escasez de medicamentos pediátricos que se encuentran en el mercado, además de las pocas indicaciones, dosificaciones y posologías específicas para niños, que encontramos en los prospectos y fichas técnicas de las especialidades farmacéuticas comercializadas. Dicha situación, junto con los problemas que presenta la realización de ensayos clínicos durante la infancia, provocan la necesidad de tratar a esta población basándonos en la experiencia clínica, y no tanto en la evidencia científica, eligiendo como alternativa más adecuada la formulación magistral que se adapta al paciente y su patología.
Pharmacy compounding offers several benefits which are increasingly recognized. The begining of pharmaceutical industry made us to forget the advantages of this art. However, the “despersonalization” that involves large-scale developing, makes the patient adapt to the treatment, which is very difficult in pediatrics. Special characteristics of this population, as well as its vulnerability, forcing us to resort to pharmacy compounding, which allows us to achieve the individualization of drug therapy. The use of this technique is emphasized by the lack of pediatric medicines and few information about indications and dosage for children. In addition, the problems of conducting clinical trials in childhood, promote that their treatment was based on clinical experience, rather than scientific evidence, choosing pharmacy compounding as the best alternative. It adapts to the patient and the disease.
Pharmacy compounding offers several benefits which are increasingly recognized. The begining of pharmaceutical industry made us to forget the advantages of this art. However, the “despersonalization” that involves large-scale developing, makes the patient adapt to the treatment, which is very difficult in pediatrics. Special characteristics of this population, as well as its vulnerability, forcing us to resort to pharmacy compounding, which allows us to achieve the individualization of drug therapy. The use of this technique is emphasized by the lack of pediatric medicines and few information about indications and dosage for children. In addition, the problems of conducting clinical trials in childhood, promote that their treatment was based on clinical experience, rather than scientific evidence, choosing pharmacy compounding as the best alternative. It adapts to the patient and the disease.