Publication: Desarrollo de formulaciones transdérmicas III
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2016
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Abstract
La piel constituye el principal organismo de defensa del cuerpo, aislándolo de la mayoría de agentes externos y protegiendo las estructuras corporales. La vía de administración transdérmica consiste en el paso de un compuesto a través de la estructura cutánea para ejercer un efecto, ya sea local o sistémico, dentro de la misma. En la actualidad el interés por el conocimiento e investigación de nuevas formulaciones transdérmicas está en aumento, ya que se trata de una vía no invasiva que no presenta efecto de primer paso, produce una liberación sostenida del fármaco y permite reducir la dosificación del principio activo. Las nuevas tecnologías, junto con los conocimientos actuales permiten el desarrollo a gran velocidad de nuevas formulaciones cuya composición se optimiza para ofrecer la mayor efectividad posible. Asimismo, estos avances en la composición de las nanopartículas permiten explorar nuevos horizontes, ampliando las utilidades terapéuticas y generando alternativas a tratamientos actuales. El objetivo de este informe consiste en conocer algunos de los avances experimentados tanto en la composición como en las aplicaciones de las formulaciones transdérmicas de nanopartículas.
Skin is the main defensive barrier of the body, isolating it from almost every external agent and protecting its internal structures. Transdermal delivery consists in the entrance of a compound through the skin layers in order to make an effect, either local or systemic, within it. Currently, the interest on the knowledge and research of new transdermal formulations is increasing, since it is a non-invasive procedure which does not undergo any first-pass effect, produces a sustained release of the drug and reduces the dosage of the active ingredient. New technologies, together with current knowledge allow a fast development of new formulations whose composition is optimized to provide the greatest possible effectiveness. In addition, these advances in the composition of the nanoparticles allow the exploration of new horizons, expanding therapeutic utilities and generating alternatives to current treatments. The objective of this report is to make some research on advances in both the composition and application of transdermal formulations of nanoparticles.
Skin is the main defensive barrier of the body, isolating it from almost every external agent and protecting its internal structures. Transdermal delivery consists in the entrance of a compound through the skin layers in order to make an effect, either local or systemic, within it. Currently, the interest on the knowledge and research of new transdermal formulations is increasing, since it is a non-invasive procedure which does not undergo any first-pass effect, produces a sustained release of the drug and reduces the dosage of the active ingredient. New technologies, together with current knowledge allow a fast development of new formulations whose composition is optimized to provide the greatest possible effectiveness. In addition, these advances in the composition of the nanoparticles allow the exploration of new horizons, expanding therapeutic utilities and generating alternatives to current treatments. The objective of this report is to make some research on advances in both the composition and application of transdermal formulations of nanoparticles.