Publication: Utilidad de la procalcitonina, pancreatic stone protein (PSP) y fracción soluble de CD25 (sCD25) como biomarcadores para el diagnóstico de infección y sepsis
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2018-11-06
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Universidad Complutense de Madrid
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Abstract
Las enfermedades infecciosas constituyen un grave problema de salud en el mundo, asociándose con una elevada morbilidad y mortalidad en todos los ámbitos de la asistencia sanitaria. De entre ellas, la sepsis forma parte del grupo de enfermedades tiempo dependiente, entendiendo como tales aquellas en las que el retraso diagnostico terapéutico influyen negativamente en la evolución del proceso y por tanto la aplicación precoz de una serie de medidas diagnostico terapéuticas, entre las que se incluyen la terapia antibiótica así como el soporte hemodinámico adecuado, mejoran de forma significativa la supervivencia y el pronóstico de este tipo de pacientes.Para el diagnóstico de estas patologías nos podemos ayudar de pruebas microbiológicas, pero, las propias características de estas pruebas suponen una limitación para un diagnóstico rápido, porque la obtención de resultados no es inmediata y además, estas pruebas pueden estar condicionadas por la toma previa de antibióticos.Por ello, la disponibilidad de otras herramientas, como los marcadores bioquímicos, probablemente en combinación con criterios clínicos, es esencial en la toma de decisiones ante este tipo de pacientes, así como la categorización de la severidad como base para la toma de decisiones diagnostico-terapéuticas, son necesarias en el manejo de esta patología, pudiendo modificar sustancialmente el pronóstico de los pacientes...
Infectious diseases are a serious health problem in the world, associated with high morbidity and mortality in all areas of health care. Among them, sepsis is part of the group of time dependent diseases, understanding as such those in which the therapeutic diagnostic delay, negatively influence the evolution of the process and therefore the early application of a series of diagnostic therapeutic measures, among which is included antibiotic therapy and adequate hemodynamic support, significantly improve patient survival and prognosis.For the diagnosis of these pathologies we can help microbiological tests, but the characteristics of these tests are a limitation for a rapid diagnosis, because the results are not immediate and in addition, these tests can be conditioned by the previous taking antibiotics.Therefore, the availability of other tools, such as biochemical markers, probably in combination with clinical criteria, is essential in the decision making of this type of patients, as well as the categorization of severity as a basis for diagnostic therapeutic decisions, are necessary in the management of this pathology, being able to modify substantially the prognosis of the patients...
Infectious diseases are a serious health problem in the world, associated with high morbidity and mortality in all areas of health care. Among them, sepsis is part of the group of time dependent diseases, understanding as such those in which the therapeutic diagnostic delay, negatively influence the evolution of the process and therefore the early application of a series of diagnostic therapeutic measures, among which is included antibiotic therapy and adequate hemodynamic support, significantly improve patient survival and prognosis.For the diagnosis of these pathologies we can help microbiological tests, but the characteristics of these tests are a limitation for a rapid diagnosis, because the results are not immediate and in addition, these tests can be conditioned by the previous taking antibiotics.Therefore, the availability of other tools, such as biochemical markers, probably in combination with clinical criteria, is essential in the decision making of this type of patients, as well as the categorization of severity as a basis for diagnostic therapeutic decisions, are necessary in the management of this pathology, being able to modify substantially the prognosis of the patients...
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacia y Tecnología Farmacéutica, leída el 17/11/2017