Publication: Desarrollo y caracterización de formulaciones de accion anitoxidante a partir de extractos de Sambucus ebulus L
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2018-11-06
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Universidad Complutense de Madrid
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Abstract
Los productos naturales, tanto directamente como en forma de preparados o extractos,suponen una fuente ilimitada de nuevos principios activos de aplicación en terapéutica dada su alta diversidad química y variedad de acciones. Constituyen así una de las bases para el desarrollo de nuevos fármacos.Las reacciones de óxido-reducción son procesos químicos esenciales en los sistemas biológicos para la formación de productos necesarios en los procesos metabólicos celulares. Estas reacciones conllevan la transferencia de electrones y pueden generar compuestos que actúan como radicales libres (RL), entre los que se encuentran las especies reactivas de oxígeno (EROs). En un entorno celular sano, los sistemas antioxidantes existentes son capaces de mantener el equilibrio entre la formación y la destrucción de estos RL. Sin embargo, cuando la producción de RL supera a su neutralización o destrucción, tienen lugar una serie de reacciones conocidas como estrés oxidativo. La pieles el órgano más expuesto de manera directa al daño oxidativo por radicales libres (RL)produciendo inflamación, eccema, cáncer, inmunosupresión o sequedad cutánea, entre otros. Actualmente existen ensayos clínicos que proporcionan evidencia del beneficio delos antioxidantes al ser aplicados de manera tópica. A consecuencia de esto, el desarrollo de productos farmacéuticos que incluyen este tipo de sustancias activas ha crecido de modo acelerado en los últimos años...
Natural products are an unlimited source of new active substances to be applied in therapeutics due to their complex chemical composition which allows a wide variety of biological activities. They become one of the main bases for the development of new drugs. Reduction-oxidation (redox) reactions are chemical processes within cellular metabolism which are essential for cell survival and development. These reactions are based in the transference of electrons between molecules and may generate different metabolites which act as free radicals; among them, oxygen-reactive species (ROS) are one of the most abundant. In healthy conditions, antioxidant mechanisms within cells are capable of maintaining the balance between the generation and neutralization or destruction of free radicals. Nonetheless, when an imbalance occurs, free radicals levels increase and a series of oxidative reactions known as oxidative stress, take place. The skin is the organ with the highest exposition to oxidative damage and this fact is shown as the development of different skin alterations such as inflammation, eczema, skin dryness, immunosuppression reactions or cancer, among others. Nowadays, several studies prove the beneficial effect of antioxidant agents when applied topically. Thus, the development of new pharmaceutical products with this kind of active substances is continuously increasing...
Natural products are an unlimited source of new active substances to be applied in therapeutics due to their complex chemical composition which allows a wide variety of biological activities. They become one of the main bases for the development of new drugs. Reduction-oxidation (redox) reactions are chemical processes within cellular metabolism which are essential for cell survival and development. These reactions are based in the transference of electrons between molecules and may generate different metabolites which act as free radicals; among them, oxygen-reactive species (ROS) are one of the most abundant. In healthy conditions, antioxidant mechanisms within cells are capable of maintaining the balance between the generation and neutralization or destruction of free radicals. Nonetheless, when an imbalance occurs, free radicals levels increase and a series of oxidative reactions known as oxidative stress, take place. The skin is the organ with the highest exposition to oxidative damage and this fact is shown as the development of different skin alterations such as inflammation, eczema, skin dryness, immunosuppression reactions or cancer, among others. Nowadays, several studies prove the beneficial effect of antioxidant agents when applied topically. Thus, the development of new pharmaceutical products with this kind of active substances is continuously increasing...
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacia y Tecnología Farmacéutica, leída el 10/07/2017