Publication: Nanosistemas para el tratamiento de la enfermedad de Alzheimer
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2016-06
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Abstract
La Enfermedad de Alzheimer representa la forma más común de demencia. Afecta a más de 35 millones de personas y se espera que estos números se incrementen de forma exponencial en los próximos años. A falta de métodos de diagnóstico precoz y de un tratamiento efectivo que frene y pueda revertir los daños neurológicos, la nanotecnología se presenta como una de las líneas de investigación más prometedoras para lograr la entrega y liberación de fármacos al sistema nervioso central, protegido por la barrera hemato-encefálica, uno de los principales obstáculos para conseguir tratamientos farmacológicos eficaces. En este trabajo se describen algunos de los nanosistemas investigados hoy en día y nos centraremos en el empleo de las nanopartículas y liposomas como alternativa de tratamiento para la enfermedad de Alzheimer.
Alzheimer’s disease represents the most common form of dementia. It affects more than 35 million people worlwide and this number is expected to increase exponencially in the next few years. In the absence of early diagnosis methods and effective treatment to halt and reverse the neurological damage, nanotechnology is presented as one of the most promising lines of research to achieve drug delivery to the central nervous system, protected by the blood-brain barrier, one of the main obstacles to carry out effective pharmacological treatments. This review describes some of the most researched nanosystems nowadays and will focus on the use of nanoparticles and liposomes as an alternative for the treatment of Alzheimer’s disease.
Alzheimer’s disease represents the most common form of dementia. It affects more than 35 million people worlwide and this number is expected to increase exponencially in the next few years. In the absence of early diagnosis methods and effective treatment to halt and reverse the neurological damage, nanotechnology is presented as one of the most promising lines of research to achieve drug delivery to the central nervous system, protected by the blood-brain barrier, one of the main obstacles to carry out effective pharmacological treatments. This review describes some of the most researched nanosystems nowadays and will focus on the use of nanoparticles and liposomes as an alternative for the treatment of Alzheimer’s disease.