Publication: Variabilidad natural en los sitios de procesamiento viral y en posiciones asociadas a resistencias antirretrovirales de la proteasa, retrotranscriptasa e integrasa en las variantes del VIH-1
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2018-11-16
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Universidad Complutense de Madrid
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Abstract
El virus de la inmunodeficiencia humana tipo 1 (VIH-1) presenta alta variabilidad genética, debida a su alta tasa de replicación, de mutación y de recombinación, describiéndose numerosas variantes. Basándose en la homología genética de sus secuencias, el VIH-1 se clasifica en cuatro grupos: M (principal), O (outlier), N (non-M, non-O) y P. A su vez, el grupo M se subdivide en 9 subtipos (A, B, C, D, F, G, H, J, K), en al menos 88 recombinantes circulantes (CRF), y múltiples recombinantes únicos. Los recombinantes se están expandiendo en la pandemia (incluido en Europa), principalmente en lugares donde circulan simultáneamente numerosas variantes diferentes. El subtipo B es la variante predominante en Europa y Estados Unidos, pero los subtipos del VIH-1 distintos al subtipo B y recombinantes (variantes no-B) causan cerca del 90% de los 37 millones de infecciones por VIH...
Human immunodeficiency virus type 1 (HIV-1) shows a high genetic diversity due to its high replication, mutation and recombination rates. A large number of HIV-1 variants have been described. Based on viral sequences homology HIV-1 has been classified into four groups: M (main), O (outlier), N (non-M, non-O) and P. HIV-1 Group M is subdivided into 9 subtypes (A–D, F–H, J, K), at least 88 circulating recombinant forms (CRF) and multiple unique recombinants (URF). Recombinants are expanding in the pandemic (including in Europe), mainly in setting with cocirculation of different HIV-1 variants. HIV-1 subtype B predominates in Europe and United States, but subtypes different than subtype B and recombinants (HIV-1 non–B variants) cause near 90% of HIV infections worldwide...
Human immunodeficiency virus type 1 (HIV-1) shows a high genetic diversity due to its high replication, mutation and recombination rates. A large number of HIV-1 variants have been described. Based on viral sequences homology HIV-1 has been classified into four groups: M (main), O (outlier), N (non-M, non-O) and P. HIV-1 Group M is subdivided into 9 subtypes (A–D, F–H, J, K), at least 88 circulating recombinant forms (CRF) and multiple unique recombinants (URF). Recombinants are expanding in the pandemic (including in Europe), mainly in setting with cocirculation of different HIV-1 variants. HIV-1 subtype B predominates in Europe and United States, but subtypes different than subtype B and recombinants (HIV-1 non–B variants) cause near 90% of HIV infections worldwide...
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología II, leída el 19/12/2017