Publication: Estado de los márgenes quirúrgicos y riesgo de recidiva locorregional en cirugía conservadora del cáncer de mama. ¿Qué distancia debe considerarse como margen afecto?
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2018-11-21
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Universidad Complutense de Madrid
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Abstract
ÁMBITO DEL ESTUDIO Unidad de Mama (Ginecología). Hospital General Universitario Gregorio Marañón.C/O’Donnell 40. 28009 Madrid.OBJETIVO PRINCIPAL Analizar el efecto de la distancia del tumor al margen y de la afectación del mismo sobre el riesgo de recidiva lo corregional. DISEÑO Estudio de cohortes retrospectivo con análisis de la supervivencia PALABRAS CLAVE Cáncer de mama, cirugía conservadora, márgenes quirúrgicos, distancia al margen,recidiva lo corregional MARCO CONCEPTUAL Y JUSTIFICACIÓN DEL ESTUDIO Un meta-análisis reciente ha establecido que, en ausencia de afectación del margen quirúrgico de resección, no se requieren distancias mínimas del tumor al margenen terapia conservadora del cáncer de mama infiltrante para minimizar el riesgo de recidiva local (RL). Para carcinoma intraductal, otros meta-análisis recomiendan distancias superiores a 1 ó 2 mm. Sin embargo, varios autores han cuestionado estos hallazgos por la metodología de estos estudios recogidos por estos meta-análisis...
AIMTo assess the effect of the distance from tumor to margin and of the involvement ofsurgical margins on the risk of locoregional recurrence (LRR).DESIGNObservational retrospective cohort study with survival analysis.KEY WORDSBreast cancer, breast conserving surgery, surgical margins, distance to margin,locoregional recurrenceBACKGROUNDFor infiltrating breast cancer, a recent meta-analysis concluded that no minimumdistance from the tumor to the margin is required in breast conserving therapy tominimize the risk of local recurrence (LR) other than no tumor on the surgicalmargin. For ductal carcinoma in situ (DCIS), another meta-analysis recommends adistance greater than 1 or 2 mm. However, several authors have questioned thesestatements due to methodological issues...
AIMTo assess the effect of the distance from tumor to margin and of the involvement ofsurgical margins on the risk of locoregional recurrence (LRR).DESIGNObservational retrospective cohort study with survival analysis.KEY WORDSBreast cancer, breast conserving surgery, surgical margins, distance to margin,locoregional recurrenceBACKGROUNDFor infiltrating breast cancer, a recent meta-analysis concluded that no minimumdistance from the tumor to the margin is required in breast conserving therapy tominimize the risk of local recurrence (LR) other than no tumor on the surgicalmargin. For ductal carcinoma in situ (DCIS), another meta-analysis recommends adistance greater than 1 or 2 mm. However, several authors have questioned thesestatements due to methodological issues...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Obstetricia y Ginecología, leída el 26-06-2017