Publication: Nuevos biomarcadores y dianas terapéuticas en cáncer colorrectal metastásico
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2018-11-21
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Universidad Complutense de Madrid
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Abstract
El cáncer colorrectal (CCR) es el cuarto cáncer más mortal a nivel mundial, debido al desarrollo metastásico de la enfermedad. Por esta razón, parte de los esfuerzos se focalizan en la predicción y el tratamiento de la metástasis de CCR.Las células tumorales metastásicas sufren una serie de alteraciones, por ejemplo en su capacidad de adhesión e invasión, que les permiten colonizar, sobrevivir y proliferar en órganos distales. Actualmente, no se conocen con exactitud los mecanismos moleculares ni las proteínas responsables de la colonización hepática y pulmonar de las células tumorales de colon. Recientemente, nuestro laboratorio identificó a CDH17 e IL13Rα2, y los mecanismos moleculares a través de los cuales son necesarias para la colonización hepática de las células de CCR.Para la búsqueda de biomarcadores asociados a enfermedades como el cáncer, se utilizan técnicas “ómicas”, que permiten identificar, cuantificar y caracterizar miles de genes o proteínas en muestras biológicas complejas. Nuestro laboratorio ha utilizado estas técnicas, como micro arrays de proteínas o proteómica cuantitativa, identificando un total de 43 antígenos asociados a tumor, entre los que se encontraban FGFR4 yPIM1, que podrían funcionar como biomarcadores del CCR. Estos avances son de gra nimportancia, ya que pocas proteínas se han descrito como biomarcadores de CCR...
Colorectal cancer (CRC) is the fourth most worldwide deadly cancer due to the metastatic development of the disease. For this reason, efforts are focused on the prediction and treatment of CRC metastases. Metastatic tumor cells undergo a series of alterations, for example in their capacity of adhesion and invasion, which allow them to colonize, survive and proliferate in distal organs. At present, molecular mechanisms and proteins responsible for hepatic and pulmonary colonization of colon tumor cells are not known. Recently, our laboratory has identified CDH17 and IL13Rα2, and the molecular mechanisms through which they function, for hepatic colonization of CCR cells. To search for biomarkers associated with diseases such as cancer, "omic" techniques are used to identify, quantify and characterize thousands of genes and/orproteins in complex biological samples. Our laboratory has used these techniques, such as protein microarrays or quantitative proteomics, identifying a total of 43 tumor associated antigens, including FGFR4 and PIM1, which could function as CRC biomarkers. These advances are of great importance, since few proteins have been described as CRC biomarkers...
Colorectal cancer (CRC) is the fourth most worldwide deadly cancer due to the metastatic development of the disease. For this reason, efforts are focused on the prediction and treatment of CRC metastases. Metastatic tumor cells undergo a series of alterations, for example in their capacity of adhesion and invasion, which allow them to colonize, survive and proliferate in distal organs. At present, molecular mechanisms and proteins responsible for hepatic and pulmonary colonization of colon tumor cells are not known. Recently, our laboratory has identified CDH17 and IL13Rα2, and the molecular mechanisms through which they function, for hepatic colonization of CCR cells. To search for biomarkers associated with diseases such as cancer, "omic" techniques are used to identify, quantify and characterize thousands of genes and/orproteins in complex biological samples. Our laboratory has used these techniques, such as protein microarrays or quantitative proteomics, identifying a total of 43 tumor associated antigens, including FGFR4 and PIM1, which could function as CRC biomarkers. These advances are of great importance, since few proteins have been described as CRC biomarkers...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 05/10/2017