Publication: Papel de la metformina en la resistencia a la insulina asociada a la inflamación en estados de obesidad
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2016-06
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Abstract
La obesidad es una patología que está incrementando de forma exponencial especialmente en los países occidentales y su creciente prevalencia va acompañada del desarrollo de otras enfermedades concomitantes tales como la Diabetes Mellitus o las enfermedades cardiovasculares, cuya gravedad es también considerable. En los últimos años se ha demostrado que la obesidad induce un estado de inflamación crónica de bajo grado asociado al incremento del tejido adiposo y, como consecuencia, se produce una resistencia a la insulina que es desencadenante de Diabetes. La complejidad de esta asociación produce una serie de consecuencias que por sus características disminuyen el estado de salud y la calidad de vida del paciente, ya que aumentan la morbilidad y la mortalidad. Diversos trabajos apuntan a que ciertos fármacos antidiabéticos, presentan también un efecto beneficioso sobre procesos inflamatorios, ejerciendio su acción por tanto a dos niveles y mejorando el desarrollo ambas patologías. La metformina, uno de los antidiabéticos orales más prescritos para el tratamiento de la Diabetes Mellitus de tipo 2, ha sido uno de los fármacos que presentan estos efectos duales. Este trabajo se centra en la revisión de dos estudios que han analizado el papel de la metformina en el proceso inflamatorio y en las propiedades antiinflamatorias de la misma.
Obesity is a pathology which is increasing exponentially, especially in western countries and its increasing prevalence is associated with the development of other concomitant diseases such as diabetes mellitus or cardiovascular diseases, whose severity is important as well. In the last few years, researches have shown obesity induces a chronic low-grade inflammation condition associated with the increase of adipose tissue, due to this fact, insulin resistance might be developed and diabetes appears as a result. The severity of this association produces different consequences which diminish the health and quality of patient’s life because of its natural characteristics, increasing morbidity and mortality probabilities. 2 Several researches suggest that certain antidiabetic agents have also positive effects on inflammatory processes. Impacting not only in one level, but improving the development of both pathologies. Metformin is one of the most prescribed oral drugs in order to treat Diabetes Mellitus Type 2, being one of the drugs with these dual effects. This project focuses on the review of two researches which have examined the role of metformin in the inflammatory process and its anti-inflammatory skills.
Obesity is a pathology which is increasing exponentially, especially in western countries and its increasing prevalence is associated with the development of other concomitant diseases such as diabetes mellitus or cardiovascular diseases, whose severity is important as well. In the last few years, researches have shown obesity induces a chronic low-grade inflammation condition associated with the increase of adipose tissue, due to this fact, insulin resistance might be developed and diabetes appears as a result. The severity of this association produces different consequences which diminish the health and quality of patient’s life because of its natural characteristics, increasing morbidity and mortality probabilities. 2 Several researches suggest that certain antidiabetic agents have also positive effects on inflammatory processes. Impacting not only in one level, but improving the development of both pathologies. Metformin is one of the most prescribed oral drugs in order to treat Diabetes Mellitus Type 2, being one of the drugs with these dual effects. This project focuses on the review of two researches which have examined the role of metformin in the inflammatory process and its anti-inflammatory skills.