Publication: Sobre la expresión de anticuerpos anti-SSA-RO/SSB-LA y su correlación clínica y serológica dentro de las enfermedades sistémicas autoinmunes
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2018-11-27
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Universidad Complutense de Madrid
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Abstract
El sistema de autoanticuerpos anti-Ro y anti-La es uno de los más útiles en la práctica clínica diaria y también de los más ampliamente estudiados debido a su alta prevalencia en la población de pacientes con ERAS. A lo largo de los años se ha descrito una gran variedad asociaciones clínicas, no siempre coincidentes. No hay prácticamente estudios que incluyan todo el espectro de las ERAS, incluyendo las variantes juveniles, y en una población homogénea étnica y geográficamente. Las evidencias actuales indican que las proteínas Ro60 kDa y Ro 52 kDa no son parte de un complejo macromolecular estable y potencialmente esto se traduce en que los AAC anti-Ro 60 kDa y anti-Ro 52 kDa condicionan asociaciones clínicas diferentes. OBJETIVO: Determinar si existen patrones clínicos relacionados con la detección de AAC anti-Ro 60 kDa, anti-Ro 52 kDa y anti-La en pacientes con ERAS, independientemente del diagnóstico...
The anti-Ro and anti-La is one of the most useful autoantibodies system in the daily clinical practice and it is the most widely studied because of its high prevalence in the systemic autoimmune rheumatic diseases(SARD). Throughout the years, great varieties of clinical associations have been described, not always being coincident. There are no studies that cover the spectrum of SARD in a homogeneous population, including juvenile variants. Current evidence indicates that the Ro 60 kDa and Ro 52 kDa proteins are not part of a stable macromolecular complex and potentially, it means that the anti-Ro 60 kDa and anti- Ro 52 kDa autoantibodies (AAB) determine distinctive clinical associations. OBJECTIVE: To determine whether there are clinical patterns related to the detection of anti-Ro 60 kDa, anti-Ro 52 kDa and anti-La in patients with SARD, regardless of primary diagnosis...
The anti-Ro and anti-La is one of the most useful autoantibodies system in the daily clinical practice and it is the most widely studied because of its high prevalence in the systemic autoimmune rheumatic diseases(SARD). Throughout the years, great varieties of clinical associations have been described, not always being coincident. There are no studies that cover the spectrum of SARD in a homogeneous population, including juvenile variants. Current evidence indicates that the Ro 60 kDa and Ro 52 kDa proteins are not part of a stable macromolecular complex and potentially, it means that the anti-Ro 60 kDa and anti- Ro 52 kDa autoantibodies (AAB) determine distinctive clinical associations. OBJECTIVE: To determine whether there are clinical patterns related to the detection of anti-Ro 60 kDa, anti-Ro 52 kDa and anti-La in patients with SARD, regardless of primary diagnosis...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 23/06/2017