Light-induced ATP release from the lens



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Pintor Just, Jesús (2018) Light-induced ATP release from the lens. Purinergic Signalling, 14 (4). pp. 499-504. ISSN 1573-9538

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The recent discovery of the photoreceptor melanopsin in lens epithelial cells has opened the possibility of modulating this protein by light stimulation. Experiments carried out on New Zealand white rabbits have demonstrated that the release of ATP from the lens to the aqueous humor can be reduced either when a yellow filter or a melanopsin antagonist is used. Compared to control (1.10 ± 0.15 μM ATP), the application of a yellow filter (λ465–480) reduced ATP in the aqueous humor 70%, while the melanopsin antagonist AA92593 reduced the presence of ATP 63% (n = 5), an effect which was also obtained with the PLC inhibitor U73122. These results indicate that when melanopsin is blocked either by the lack of light, a filter, or an antagonist, the extracellular presence of ATP is significantly reduced. This discovery may be relevant, on the one hand, because many ocular physiological processes are controlled by ATP and, on the other hand, because it is possible to stimulate ATP release with just light and without using any added substance.

Item Type:Article
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Received: 31 May 2018; Accepted: 14 September 2018; First Online: 20 September 2018

Uncontrolled Keywords:AA92593; ATP; Eye; Lens; Light; Melanopsin
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:50832
Deposited On:22 Jan 2019 08:15
Last Modified:22 Jan 2019 08:15

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