Publication: El receptor de quimioquinas CCR7 induce ubiquitinación de proteínas en el núcleo de las células dendríticas
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2019-02-07
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Universidad Complutense de Madrid
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Abstract
Las células dendríticas (CDs) son células presentadoras de antígenos que desempeñan un papel crucial en el comienzo de la respuesta inmunológica adaptativa. En los tejidos y antes de su encuentro con el antígeno, las CDs se encuentran en un estado inmaduro, sin embargo, cuando las CDs inmaduras se exponen a patógenos u otras “señales de peligro”, sufren un proceso denominado maduración o activación durante el cual, entre otros cambios, se produce el incremento en la expresión del receptor de quimioquinas CCR7. Este receptor controla la migración de las CDs maduras desde el foco de inflamación hacia los ganglios linfáticos, siguiendo un gradiente de concentración sus ligandos, CCL19 y CCL21. En los ganglios, las CDs presentarán los antígenos endocitados a los linfocitos T específicos para generar una respuesta adaptativa. Además de la quimiotaxis, CCR7 regula otras funciones en las CDs, como la maduración, la supervivencia, la endocitosis, la citoarquitectura y la velocidad migratoria...
Dendritic cells (DCs) are potent antigen presenting cells, key for the development of an adaptive immune response. DCs are found in peripheral tissues in an immature state, but when these cells encounter a pathogen or a “danger signal”, they undergo a process called maturation, in which, they upregulate the expression of chemokine receptor CCR7. This receptor controls the migration of DCs from the inflammation site to the lymph nodes, following the concentration gradient of its ligands, chemokines CCL19 and CCL21. In the lymph nodes, DCs will present the antigens endocyted to specific T cells to activate an adaptive response. In addition to chemotaxis, CCR7 controls other functions in DCs, such as maturation, survival, endocytosis, cytoarchitecture and migratory speed.The SCF complex (Skp1-Cul-1-Fbox containing complex) is an E3 ubiquitin ligase enzyme that mediates the ubiquitination of a large number of proteins in the cell to induce their degradation by the ubiquitin proteasome system. This complex contains the proteins Skp1, Rbx1 and Cul-1. For SCF to be activated, Cul-1 has to be modified covalently by Nedd8, an ubiquitin-like protein. This process is called neddylation...
Dendritic cells (DCs) are potent antigen presenting cells, key for the development of an adaptive immune response. DCs are found in peripheral tissues in an immature state, but when these cells encounter a pathogen or a “danger signal”, they undergo a process called maturation, in which, they upregulate the expression of chemokine receptor CCR7. This receptor controls the migration of DCs from the inflammation site to the lymph nodes, following the concentration gradient of its ligands, chemokines CCL19 and CCL21. In the lymph nodes, DCs will present the antigens endocyted to specific T cells to activate an adaptive response. In addition to chemotaxis, CCR7 controls other functions in DCs, such as maturation, survival, endocytosis, cytoarchitecture and migratory speed.The SCF complex (Skp1-Cul-1-Fbox containing complex) is an E3 ubiquitin ligase enzyme that mediates the ubiquitination of a large number of proteins in the cell to induce their degradation by the ubiquitin proteasome system. This complex contains the proteins Skp1, Rbx1 and Cul-1. For SCF to be activated, Cul-1 has to be modified covalently by Nedd8, an ubiquitin-like protein. This process is called neddylation...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 27-06-2018