Publication: Anticuerpos antifosfolipídicos de clase IgA como factor de riesgo para morbi-mortalidad cardiovascular en el trasplante de órganos sólidos
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2019-02-18
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Universidad Complutense de Madrid
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Abstract
En las últimas décadas han mejorado los resultados del trasplante renal, a corto y largo plazo, gracias a la introducción de la inmunosupresión moderna, los avances en el control de infecciones, mejores metodologías quirúrgicas y los avances en el conocimiento de la respuesta inmune y las técnicas de histocompatibilidad. Sin embargo, las pérdidas del injerto en los primeros meses tras el trasplante apenas han registrado cambios (5-8% de los trasplantes), siendo la principal causa la trombosis del injerto.Uno de los principales factores responsables del deterioro de la función del órgano transplantado después del trasplante es la respuesta inmune frente al aloinjerto. Desde hace años se conoce que el principal objetivo de este ataque inmunitario es el complejo principal de histocompatibilidad (CPH) del donante (alorreactividad) aunque recientemente se ha informado que también respuestas autoinmunes basadas en anticuerpos dirigidos frente a otras moléculas distintas del CPH también pueden afectar el resultado del trasplante renal. El síndrome antifosfolípido (APS) es un trastorno autoinmune caracterizado por la presencia de trombosis y o morbilidad gestacional en paciente que en su sangre tienen anticuerpos antifosfolipídícos (aPL). Los aPL están dirigidos frente a fosfolípidos, proteínas plasmáticas de unión a fosfolípidos, o el complejo formado por ambos unión de ambos...
In recent decades, the short and long term outcomes of renal transplantation have improved, thanks to the introduction of modern immunosuppression, advances in infection control, better surgical methodologies, and advances in the knowledge of the immune response and the histocompatibility techniques. However, graft losses in the first months after transplantation have barely registered changes (5-8% of transplants), the main cause is by graft thrombosis. One of the main factors responsible for the deterioration of graft function is the immuneresponse against the allograft. For years it has been known that the main target of this immune attack is the donormajor histocompatibility complex (MHC), although it has recently been reported that autoimmune responses based on antibodies directed against molecules other than MHCcan also affect the result of the kidney transplant.The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of thrombosis and / or gestational morbidity in patients who have antiphospholipid antibodies (aPL) in the blood. The aPL are directed against phospholipids, plasma proteins binding to phospholipids, or the complex formed by union of both...
In recent decades, the short and long term outcomes of renal transplantation have improved, thanks to the introduction of modern immunosuppression, advances in infection control, better surgical methodologies, and advances in the knowledge of the immune response and the histocompatibility techniques. However, graft losses in the first months after transplantation have barely registered changes (5-8% of transplants), the main cause is by graft thrombosis. One of the main factors responsible for the deterioration of graft function is the immuneresponse against the allograft. For years it has been known that the main target of this immune attack is the donormajor histocompatibility complex (MHC), although it has recently been reported that autoimmune responses based on antibodies directed against molecules other than MHCcan also affect the result of the kidney transplant.The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of thrombosis and / or gestational morbidity in patients who have antiphospholipid antibodies (aPL) in the blood. The aPL are directed against phospholipids, plasma proteins binding to phospholipids, or the complex formed by union of both...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 12/12/2018. Tesis formato europeo (compendio de artículos)