Yellow Filter Effect on Melatonin Secretion in the Eye: Role in IOP Regulation



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LLedó Mayans, Victoria Eugenia and Alkozi, Hanan Awad and Pintor Just, Jesús (2019) Yellow Filter Effect on Melatonin Secretion in the Eye: Role in IOP Regulation. Current Eye Research . ISSN 0271-3683 (In Press)

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Purpose: Melatonin is a neurohormone mainly synthesized in the pineal gland; however, it is also present in the aqueous humor. One of melatonins’ functions in the eye is the regulation of intraocular pressure (IOP). Melatonin is known to be sensitive to light. Recently, the photopigment which controls melatonin synthesis, melanopsin, was found in the crystalline lens. Therefore, light conditions are an interesting possible way of regulating melatonin levels in the aqueous humor. The current study used yellow filters, since melanopsin is activated by short wavelength (blue light).
Methods: New Zealand white rabbits were used, divided in two groups, one under controlled 12 h light/dark cycles, while the rest had their cages encased with a yellow filter (λ 465–480). IOP measurements were taken every week at the same time before they were anesthetized for aqueous humor extraction.
Results: Keeping the rabbits under the yellow filter resulted in a decrease in IOP up to 43.8 ± 7.8% after 3 weeks. This effect was reversed after the topical application of selective and nonselective melatonin receptors antagonists, 4PPDOT and luzindole. Also, blocking melanopsin by its antagonist AA92593 under white light condition decreased IOP. Finally, melatonin levels were found significantly higher in the aqueous humor of rabbits developed under yellow filter compared to controls (37.4 ± 4.2 and 15.3 ± 3.1 ng/ml, respectively).
Conclusion: Yellow filters modulate melatonin levels in the aqueous humor due to deactivating melanopsin activity. This effect leads to a decrease in IOP mediated by melatonin receptors.

Item Type:Article
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Received 19 Oct 2018, Accepted 07 Jan 2019, Accepted author version posted online: 14 Jan 2019, Published online: 24 Jan 2019.
This is an Accepted Manuscript of an article published by Taylor & Francis in Journal Current Eye Research on 24-01-2019, available online:

Uncontrolled Keywords:Yellow filter, Intraocular pressure, Melatonin, Melanopsin
Subjects:Sciences > Chemistry > Biochemistry
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:51541
Deposited On:27 Feb 2019 14:26
Last Modified:24 Jan 2020 00:01

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