The influence of meibomian gland loss on ocular surface clinical parameters



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Rico del Viejo, Laura and Benítez del Castillo, José Manuel and Gómez Sanz, Fernando Javier and García Montero, María and Llorens Quintana, Clara and Madrid Costa, David (2019) The influence of meibomian gland loss on ocular surface clinical parameters. Contact Lens and Anterior Eye . ISSN 1367-0484

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Purpose: To assess the relationship between the meibomian gland loss (MGL) and relevant ocular surface clinical parameters as well as the influence of age in this relationship.
Methods: A total of 161 participants (mean age; 42±17 years) were enrolled in this study. Infrared meibography was performed using Keratograph 5M (K5M; Oculus GmbH, Wetzlar). Participants were divided into five groups according to total meiboscore and the ocular surface parameters of each MGL group were studied. In addition, the relationship between MGL and the ocular surface parameters was established including age as covariant.
Results: Both eyelids were taken into account since no association between the MGL from upper and lower eyelid was found (k value=0.2; p=0.3) despite they were significantly correlated (r= 0.3; p<0.001). No statistically significant differences were found in symptomatology among different MGL groups. Statistically significant differences were found among MGL groups in tear osmolarity (p=0.02), bulbar redness (p=0.04), corneal and conjunctival staining (p=0.01 and p=0.004, respectively). Despite this, only corneal staining showed a significant correlation with MGL when age was covariant (r=0.2; p=0.04).
Conclusions: MGL higher than 50% seems to be accompanied by signs on the ocular surface. Furthermore, age demonstrated to be a relevant factor when assessing MGL. For this reason, future studies should compare age-matched groups in order to know the contribution of the MGL on the ocular surface and establish valid cut-off values for dry eye diagnosis.

Item Type:Article
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Received 19 December 2018, Revised 31 March 2019, Accepted 3 April 2019, Available online 10 April 2019.

Uncontrolled Keywords:Meibomian gland loss; Infrared Meibography; Ocular surface; Tear film; Symptomatology; Age
Subjects:Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Physiological optics
Medical sciences > Optics > Imaging systems
ID Code:55124
Deposited On:30 Apr 2019 11:43
Last Modified:10 Apr 2020 23:01

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