Publication: Functionalized biomaterials for tissue engineering. Biomateriales funcionalizados para ingeniería de tejidos
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2019-05-22
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Universidad Complutense de Madrid
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Abstract
La ingeniería de tejidos ha establecido un nuevo paradigma en la medicina: las propiedades de los biomateriales modernos han de cumplir diversas funciones relacionadas con las necesidades de la sociedad, las cuales varían según los grupos de edad específicos y las distintas enfermedades de los pacientes. La revisión bibliográfica realizada en la Introducción de esta Tesis Doctoral aborda los mecanismos de regeneración ósea y revela las estrategias que han sido empleadas en el pasado por varias generaciones de biomateriales. Además, se analizan tanto los materiales tradicionales como los recientemente desarrollados para su aplicación como implantes permanentes y temporales. La modificación de la superficie de estos implantes se ha confirmado como la principal estrategia aplicada para la funcionalización de biomateriales. Por ello, se discuten las técnicas más importantes que conducen a la modificación simultánea de la composición y la topografía de la superficie de los materiales base. Asimismo, se revisan los avances en la generación de biomateriales híbridos a través de la combinación de materiales tratados superficialmente con la adición de capas poliméricas y se relacionan con la ingeniería de monocapas celulares..
Tissue engineering has introduced a new paradigm in medical care: the properties of modern biomaterials have to address multiple functions related to the needs of specific age groups of the patients and different diseases. The literature review carried out in the Introduction of the Thesis approaches the specificities of bone regeneration mechanisms and discloses how these have been addressed in the past by several generations of biomaterials. Both the traditional and newly developed materials for permanent and temporary implant applications are reviewed. Surface modification is revealed as the main strategy employed for functionalization of biomaterials. The most important surface modification techniques that lead to simultaneous modification of the composition and topography of the surface of the core materials are discussed. Advances in hybridization of biomaterials via combination of surface treated core materials with polymeric top-coat systems and cell sheet engineering are reviewed...
Tissue engineering has introduced a new paradigm in medical care: the properties of modern biomaterials have to address multiple functions related to the needs of specific age groups of the patients and different diseases. The literature review carried out in the Introduction of the Thesis approaches the specificities of bone regeneration mechanisms and discloses how these have been addressed in the past by several generations of biomaterials. Both the traditional and newly developed materials for permanent and temporary implant applications are reviewed. Surface modification is revealed as the main strategy employed for functionalization of biomaterials. The most important surface modification techniques that lead to simultaneous modification of the composition and topography of the surface of the core materials are discussed. Advances in hybridization of biomaterials via combination of surface treated core materials with polymeric top-coat systems and cell sheet engineering are reviewed...
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Tesis de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Bioquímica y Biología Molecular, leída el 14-12-2018