Doped-iron oxide nanocrystals synthesized by one-step aqueous route for multi-imaging purposes



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Luengo, Yurena and Roldán, Manuel A. and Varela del Arco, María and Herranz, Fernando and Morales, M. Puerto and Veintemillas Verdaguer, Sabino (2019) Doped-iron oxide nanocrystals synthesized by one-step aqueous route for multi-imaging purposes. Journal of physical chemistry C, 123 (12). pp. 7356-7365. ISSN 1932-7447

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New doped inorganic nanocrystals (NC) consisting on iron oxide and other metal integrated into the structure have been synthesized in one-step by adapting the oxidant precipitation synthesis route for magnetite. Different metals have been chosen to confer extra and unique properties to the resulting magnetic hetero-nanostructure: Co and Gd for enhancing transversal and longitudinal relaxivities for magnetic resonance imaging and Bi and Au for achieving X-ray absorption for computed tomography imaging. Apart of that, gold optical properties are interesting for photothermal therapy and iron oxides for magnetic hyperthermia. All metals have been incorporated into the magnetite structure in different ways during the synthesis: by forming a solid solution, by modifying the surface of the NCs, or by co-crystallization with the magnetite. The nanostructure formed in each case depends on the ionic radius of the secondary metal ion and the solubility of its hydroxide that control the co-precipitation in the initial steps of the reaction. Magnetic properties and imaging capabilities of the hetero-nanostructures have been analyzed as a function of the element distribution. Due to the synergistic combination of the different element properties, these magnetic hetero-nanostructures have great potential for biomedical applications.

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©2019 American Chemical Society
Thanks to the general services from ICMM (X-ray, ICP) and URJC, in particular to Jesus Gonzalez for TEM images, and to the NAP group of Institute of Nanoscience of Aragon (INA), in particular to Laura Asín and Lucía Gutiérrez for the SAR measurement assistance. The work has been supported by the Spanish Ministerio de Ciencia, Innovacion y Universidades under the following projects: Project MAT2017-88148-R and PIE-201760E007. STEM/EELS observations at Oak Ridge National Laboratory (ORNL) U.S. Department of Energy (DOE), Basic Energy Sciences (BES), Materials Sciences and Engineering Division and through the Center for Nanophase Materials Sciences (CNMS), which is sponsored by the Scientific User Facilities Division, DOE-BES. Research at UCM supported by MINECO-FEDER MAT2015-66888-C3-3-R. Thanks to SAF2016-79593-P project and to Nanobioap cluster of excellence supported by the Ministry of Economy and Competitiveness of Spanish Government through MAT2016-81955-REDT.

Uncontrolled Keywords:Dual-modal mri; Contrast agents; Magnetite nanoparticles; Shell nanoparticles; Size; T-1; Gadolinium(III); Precipitation; Efficiency; Therapy
Subjects:Sciences > Physics > Materials
Sciences > Physics > Solid state physics
ID Code:55392
Deposited On:28 May 2019 15:37
Last Modified:28 Mar 2020 00:01

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