Long-term effect of intravitreal ranibizumab therapy on retinal nerve fiber layer in eyes with exudative age-related macular degeneration



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Valverde Megías, Alicia and Ruiz Calvo, Aurora and Murciano Cespedosa, Antonio and Hernández Ruiz, Samuel and Martínez de la Casa, José María and García Feijoo, Julián (2019) Long-term effect of intravitreal ranibizumab therapy on retinal nerve fiber layer in eyes with exudative age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology, 257 (7). pp. 1459-1466. ISSN 0721-832X

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Official URL: https://doi.org/10.1007/s00417-019-04325-y


Purpose: To investigate long-term effect (96 months) of intravitreal ranibizumab administered for exudative age-related macular degeneration (AMD) on retinal nerve fiber layer (RNFL) thickness when used following a pro re nata regimen.
Methods: In this prospective study, 20 eyes of 20 patients diagnosed with exudative AMD were included. Contralateral non-exudative AMD eyes of nine of these patients were included as controls. Data on intraocular pressure (IOP) and number of injections were recorded. Spectralis optic coherence tomography (OCT) of the circumpapillary RNFL was performed under dilation when diagnosis was made and before the three loading injections. “Follow-up” software was selected to accurately compare baseline with subsequent images through the 8 years of the study.
Results: Baseline IOP was 14.1 mmHg both in study (standard deviation, SD: 0.8) and control eyes (SD: 0.9) and remained unchanged during the study. Mean number of injections was 21 (SD: 2.8) at the end of the study. Mean average thickness of RNFL in the study eye group at the end of the study was 96.5 μm (SD: 2.1). Mean loss for the study period was 5.3 μm (SD: 0.7; p < 0.0001). Corresponding RNFL values for controls were 92.9 (SD: 3.2) and 5.8 μm (SD: 1.2; p < 0.001). Superior temporal sector had the greatest loss in both groups, followed by inferior and nasal sectors. No statistically significant differences were found when comparing losses in injected eyes versus control eyes.
Conclusions: RNFL thickness decreased both equally in injected eyes and control eyes. Thus, no long-term effects of intravitreal ranibizumab were observed on the retinal nerve fiber layer thickness.

Item Type:Article
Additional Information:

Received: 19 January 2019; Revised: 18 March 2019; Accepted: 11 April 2019; First Online: 03 May 2019

Uncontrolled Keywords:Nerve fiber layer; Anti-VEGF; OCT; AMD; Ranibizumab
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:55736
Deposited On:14 Jun 2019 07:19
Last Modified:14 Jun 2019 07:19

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