Publication: Tratamiento personalizado: medicamentos fabricados con impresora 3D
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2017-06
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Abstract
La impresión 3D pretende adaptar la fabricación de los medicamentos a los requerimientos específicos de cada paciente, atendiendo a su edad, peso, perfil farmacogenético, comorbilidades, así como a su farmacocinética característica. Para ello, la fabricación aditiva dispone de diferentes técnicas como la impresión 3D por inyección de tinta, a demanda o en continuo; la tecnología por deposición de material, que engloba la deposición de material fundido y la tecnología PAM y; la impresión 3D por láser, que incluye la estereolitografía. Así pues, un objetivo concreto de esta revisión es dar una visión general sobre las ventajas, desventajas y exigencias que demandan cada una de las técnicas. Del mismo modo, se contrastan las perspectivas competitivas que ofrece la impresión 3D, evidenciadas con la aprobación de Spritam® por parte de la FDA, con la aparición de dispositivos personalizados para diversos tratamientos y, con el Bioprinting como aplicación concreta a la Ingeniería de tejidos.
3D Printing aims to adapt drug’s manufacture to the specific requirements of each patient, taking into account their age, weight, pharmacogenetic profile, comorbidities, as well as their characteristic pharmacokinetics. For that, additive manufacturing has different techniques such as printing-based inkjet systems, in a continuous way or on demand; nozzlebased deposition systems, which includes fused-deposition modeling and pressure-assisted microsyringes and; laser-based writing systems that constitutes the stereolithography technique. Thus, a definite objective of this review is an overview of the advantages, disadvantages and requests required by each of the technologies. Likewise, the competitive perspective offered by 3D printing are going to be mentioned like the approval of Spritam® by the FDA, the appearance of custom devices for various treatments and, Bioprinting as the specific device to the Tissue engineering.
3D Printing aims to adapt drug’s manufacture to the specific requirements of each patient, taking into account their age, weight, pharmacogenetic profile, comorbidities, as well as their characteristic pharmacokinetics. For that, additive manufacturing has different techniques such as printing-based inkjet systems, in a continuous way or on demand; nozzlebased deposition systems, which includes fused-deposition modeling and pressure-assisted microsyringes and; laser-based writing systems that constitutes the stereolithography technique. Thus, a definite objective of this review is an overview of the advantages, disadvantages and requests required by each of the technologies. Likewise, the competitive perspective offered by 3D printing are going to be mentioned like the approval of Spritam® by the FDA, the appearance of custom devices for various treatments and, Bioprinting as the specific device to the Tissue engineering.