Photoacoustic dose monitoring in clinical high-energy photon beams



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Giza, Olivia M. and Sánchez Parcerisa, Daniel and Sánchez-Tembleque Verbo, Victor and López Herráiz, Joaquín and Camacho, Jorge and Avery, Stephen and Udías Moinelo, José Manuel (2019) Photoacoustic dose monitoring in clinical high-energy photon beams. Biomedical physics and engineering express, 5 (3). ISSN 2057-1976

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This work describes all stages of development (setup, optimization, performance, and first experimental measurements) of an acoustic sensor that can be used for range monitoring and dosimetry of clinical radiotherapy beams. The detection device consists of an ultrasonic transducer, a combination of preamplifiers and differential amplifiers with filtered outputs and a digital oscilloscope. Simulations of the experimental setup were carried out to study the optimal measurement geometry and choice of transducer. The dose distributions were calculated with the Monte Carlo code FLUKA, while the acoustic simulations were performed with the analytical wave transport code k-Wave. The temporal profiles of the dose pulses, in the order of mu s, were measured with a scintillating crystal coupled to a photomultiplier and used as input for the acoustic simulation. Measurements were performed in a Cyberknife (TM) radiosurgery beam and a TrueBeam unit. A lead block was submerged in water and placed partially or totally in the irradiation field in order to increase the acoustic signal. Photoacoustic signals were detected with both beams with the expected shape and time-delay, after the frequency response of the detection system was taken into account. The proposed setup can detect photoacoustic signals originating from the penumbra of the treatment fields after being processed with the appropriate image analysis tools.

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© 2019 IOP Publishing Ltd. Work supported by the Spanish Government (FPA2015-65035-P, RTC-2015-3772-1), Comunidad de Madrid (S2013/MIT-3024 TOPUS-CM) and European Regional Funds. This is a contribution for the Moncloa Campus of International Excellence, 'Grupo de Física Nuclear-UCM', Ref. 910059. The authors want to thank the service of Medical Physics of Hospital Ruber Internacional, especially Francisco Fayos and Elena Antolín, for their support and assistance during the experiments, as well as the protoacoustics team at UPenn (Kevin Jones, Wei Nie, Ali Kassaee) for their help and valuable discussions.

Uncontrolled Keywords:Acoustic computed-tomography; Proton-beam; Range verification; Feasibility; Parameters; Speed; Waves
Subjects:Sciences > Physics > Nuclear physics
ID Code:56315
Deposited On:28 Aug 2019 08:32
Last Modified:01 May 2020 23:01

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