Publication: Estudio epidemiológico de la enfermedad neumocócica invasora en el Hospital Universitario Severo Ochoa de Leganés
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2019-08-23
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Universidad Complutense de Madrid
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Abstract
S. pneumoniae es causante de dos formas distintas de enfermedad: no invasora e invasora (ENI). La ENI es Enfermedad de Declaración Obligatoria en la Comunidad Autónoma de Madrid (CAM) desde 2007 y sus principales formas clínicas son la neumonía bacteriémica, bacteriemia, sepsis, meningitis, artritis séptica, endocarditis y peritonitis. Es una enfermedad con gran morbimortalidad en nuestro medio y prevenible mediante vacunación. Actualmente existen distintos tipos de vacuna frente a S. pneumoniae comercializadas concretamente la conjugada (VCN_13) y la polisacárida (VPN_23). Desde 2010 la introducción y retirada en el calendario vacunal infantil sistemático de la vacuna conjugada ha modificado tanto la cobertura vacunal poblacional como la presión de los distintos serotipos de neumococo circulantes, modificando tanto la incidencia de ENI como en la morbilidad asociada a la misma...
S. pneumoniae causes two different clinical forms; non-invasive and invasive (IPD). IPD is a notifiable disease in the Autonomous Community of Madrid (CAM) since 2007 and its main clinical forms are bacteriemic pneumonia, bacteriemia, sepsis, meningitis, septic arthitis, endocarditis and peritonitis. IPD has a great impact on patient morbidity and mortality in our environment and is a vaccine-preventable disease.At this time, two forms of the vaccine are available, specifically anti-pneumococcal conjugate vaccine (VCN-13) and pneumococcal polysaccharide vaccine (VPN-23). Since 2010, the introduction and withdrawal of conjugate vaccine in the calendar has altered both vaccine coverage and serotype circulating with and impact on occurrence of IPD and the morbidity associated to it...
S. pneumoniae causes two different clinical forms; non-invasive and invasive (IPD). IPD is a notifiable disease in the Autonomous Community of Madrid (CAM) since 2007 and its main clinical forms are bacteriemic pneumonia, bacteriemia, sepsis, meningitis, septic arthitis, endocarditis and peritonitis. IPD has a great impact on patient morbidity and mortality in our environment and is a vaccine-preventable disease.At this time, two forms of the vaccine are available, specifically anti-pneumococcal conjugate vaccine (VCN-13) and pneumococcal polysaccharide vaccine (VPN-23). Since 2010, the introduction and withdrawal of conjugate vaccine in the calendar has altered both vaccine coverage and serotype circulating with and impact on occurrence of IPD and the morbidity associated to it...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 17-05-2019