Publication: Aproximación fenotípica y molecular a la inducción y detección de resistencia a equinocandinas en Candida glabrata
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2019-08-27
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Universidad Complutense de Madrid
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Abstract
El estudio de la candidemia causada por C. glabrata ha recibido gran interés fundamentalmente por el aumento de su incidencia. A esto se le suma el ascenso en la tasa de resistencia a candinas (multirresistencia en algunos casos) en ciertas zonas geográficas, lo que restringe el uso de estos antifúngicos como tratamiento de primera línea. La detección rápida de las cepas resistentes es una necesidad para mejorar el manejo del paciente y su pronóstico.Esta tesis ha pretendido dar luz a algunos interrogantes sobre el desarrollo y detección de resistencia a equinocandinas en C. glabrata mediante estudios estructurados en los siguientes tres capítulos: Capítulo I, Adquisición in vitro de resistencia secundaria a equinocandinas en aislados de C. glabrata y mecanismos moleculares implicados; Capítulo II, Determinación de parámetros cinéticos de crecimiento in vitro en aislados de Candida spp.; y Capítulo III, Detección rápida de resistencia a equinocandinas en Candida spp...
The study of C. glabrata causing candidemia has notoriously received attention due to the raise in the incidence of the infection. Moreover, an increase in the candin resistance rate (multi-resistance in some cases) has been detected in some geographical areas, thus restraining the use of candins as first-line drugs. Therefore, a rapid detection of resistant isolates should be a must in order to improve the management and prognosis of patients.This thesis aimed to enlighten some caveats on the acquisition and detection of resistance to echinocandins in C. glabrata isolates in studies grouped into the following chapters: Chapter I, In vitro resistance secondary acquisition to echinocandins in isolates of C. glabrata and molecular mechanisms involved; Chapter II, Determination in vitro growth kinetic parameters in Candida spp. and Chapter III, Rapid detection of echinocandin resistance in Candida spp...
The study of C. glabrata causing candidemia has notoriously received attention due to the raise in the incidence of the infection. Moreover, an increase in the candin resistance rate (multi-resistance in some cases) has been detected in some geographical areas, thus restraining the use of candins as first-line drugs. Therefore, a rapid detection of resistant isolates should be a must in order to improve the management and prognosis of patients.This thesis aimed to enlighten some caveats on the acquisition and detection of resistance to echinocandins in C. glabrata isolates in studies grouped into the following chapters: Chapter I, In vitro resistance secondary acquisition to echinocandins in isolates of C. glabrata and molecular mechanisms involved; Chapter II, Determination in vitro growth kinetic parameters in Candida spp. and Chapter III, Rapid detection of echinocandin resistance in Candida spp...
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología II, leída el 31-05-2019.