Publication: Caracterización de la respuesta inmune frente a "Leishmania" en individuos inmunodepresivos
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2019-08-29
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Universidad Complutense de Madrid
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Abstract
La leishmaniasis comprende un conjunto de enfermedades infecciosas causadas por protozoos parásitos, intracelulares obligados, del género Leishmania. La enfermedad tiene cuatro manifestaciones clínicas principales: leishmaniasis cutánea, leishmaniasis mucocutánea, leishmaniasis visceral y leishmaniasis dérmica post-Kala-azar. La leishmaniasis es endémica en más de 98 países, incluidos España donde está causada por Leishmania infantum. Desde el año 2009, en el que se declaró un brote en la zona sudoeste de la Comunidad de Madrid, se han reportado más de 700 casos en esa área, principalmente en el municipio de Fuenlabrada. En la actualidad, existe la necesidad de un test de referencia que permita medir la respuesta inmune tras el tratamiento, monitorizar la cura y predecir las recaídas de los pacientes. Además, la mayoría de las infecciones permanecen asintomáticas, las cuales no son detectadas debido a que no existe un test de referencia, lo que dificulta conocer la extensión real de la infección por Leishmania...
Leishmaniasis comprises a set of infectious diseases caused by parasitic, obligate intracellular protozoa of the genus Leishmania. The disease has four main clinical manifestations: cutaneous leishmaniasis, mucocutaneous leishmaniasis, visceral leishmaniasis and post-Kala-azar dermal leishmaniasis. Leishmaniasis is endemic in more than 98 countries, including Spain where it is caused by Leishmania infantum. Since 2009, when an outbreak was declared in the southwestern area of the Community of Madrid, more than 700 cases have been reported in that area, mainly in the municipality of Fuenlabrada. Currently, there is a need for a reference test to measure the immune response after treatment, monitor the cure and predict relapse of patients. In addition, most infections remain asymptomatic, which are not detected because there is no reference test, which makes it difficult to know the true extent of Leishmania infection...
Leishmaniasis comprises a set of infectious diseases caused by parasitic, obligate intracellular protozoa of the genus Leishmania. The disease has four main clinical manifestations: cutaneous leishmaniasis, mucocutaneous leishmaniasis, visceral leishmaniasis and post-Kala-azar dermal leishmaniasis. Leishmaniasis is endemic in more than 98 countries, including Spain where it is caused by Leishmania infantum. Since 2009, when an outbreak was declared in the southwestern area of the Community of Madrid, more than 700 cases have been reported in that area, mainly in the municipality of Fuenlabrada. Currently, there is a need for a reference test to measure the immune response after treatment, monitor the cure and predict relapse of patients. In addition, most infections remain asymptomatic, which are not detected because there is no reference test, which makes it difficult to know the true extent of Leishmania infection...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Parasitología, leída el 11-07-2019