Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors



Downloads per month over past year

Álvarez, Rafael and Muñoz-Piña, Sandra and González, Maria U. and Izquierdo-Barba, Isabel and Fernández-Martín, Iván and Rico, Victor J. and Arcos Navarrete, Daniel and García-Valenzuela, Aurelio and Palmero, Alberto and Vallet Regí, María and González-Elipe, Agustín R. and García-Martín, José R. (2019) Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors. Nanomaterials, 9 (9). p. 1217. ISSN 2079-4991

[thumbnail of Revised Manuscript_nanomaterials-574473.pdf]

Official URL:


Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (Depuy Synthes) and a pseudo-rectangular bone plate extracted from a patient have been coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments have been performed: analysis of bacterial adhesion and biofilm formation, and osteoblasts-bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior towards osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.

Item Type:Article
Additional Information:

RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Magnetron Sputtering; Oblique Angle Deposition; Nanostructured Titanium Thin Films; Antibacterial Coatings; Osteoblast Proliferation; Industrial Scale
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:56893
Deposited On:04 Oct 2019 11:32
Last Modified:04 Oct 2019 11:43

Origin of downloads

Repository Staff Only: item control page