Publication: Sistemas de liberación entérica para el tratamiento de afecciones locales y sistémicas
Loading...
Official URL
Full text at PDC
Publication Date
2017-06
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Citations
Exportar
Abstract
Los sistemas de liberación entérica son sistemas que retrasan la liberación del principio activo hasta el intestino delgado. Este mecanismo permite administrar fármacos que se degradan a pH ácido o que dañan el estómago sin que ninguno de estos problemas ocurra. Estos sistemas utilizan diferentes estrategias para conseguir su objetivo. Algunos de ellos utilizan polímeros resistentes a pH ácido y solubles a pH intestinal. Otros sistemas utilizan mecanismos que no tienen relación con el pH sino con el tiempo. Presentan barreras que impiden la liberación del fármaco, y que para sortearlas lo que se necesita es tiempo. Así el fármaco se liberaría justo cuando el sistema pasa por el intestino delgado. Estos y otros sistemas, y nuevas investigaciones galénicas, permiten avanzar en este campo y usar estos avances para tratar diferentes patologías locales y sobre todo sistémicas. De esta manera la terapéutica avanza y mejora, y con ello la salud de los pacientes.
Enteric delivery systems delay the release of the active substance until its arrive into the small intestine. This mechanism allows the administration of low pH-sensitive drugs and those harmful to stomach. These systems use different strategies to achieve their goal. Some systems use polymers resistant to acid pH and soluble to intestinal pH. Other systems use mechanisms not related to pH, but they are controlled by time. They present barriers that prevent the release of the drug. Those barriers are overcome with the passing time. Thus, the drug would be released after a time, just when the system passes through the small intestine. These and other systems, and new advances in galenic research, allow us to improve in this field and use these advances to treat different local pathologies and, especially, systemic pathologies. Therefore, therapy advances and improves, as well as patients´ health.
Enteric delivery systems delay the release of the active substance until its arrive into the small intestine. This mechanism allows the administration of low pH-sensitive drugs and those harmful to stomach. These systems use different strategies to achieve their goal. Some systems use polymers resistant to acid pH and soluble to intestinal pH. Other systems use mechanisms not related to pH, but they are controlled by time. They present barriers that prevent the release of the drug. Those barriers are overcome with the passing time. Thus, the drug would be released after a time, just when the system passes through the small intestine. These and other systems, and new advances in galenic research, allow us to improve in this field and use these advances to treat different local pathologies and, especially, systemic pathologies. Therefore, therapy advances and improves, as well as patients´ health.