Publication: Replicación del ADN mitocondrial humano a nivel de moléculas individuales: síntesis de la cadena retrasada
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2019-11-20
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Universidad Complutense de Madrid
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Abstract
La mitocondria es un organulo celular esencial para el metabolismo celular. Produce el ATP y juega un papel fundamental en procesos relacionados con la señalizacion celular, apoptosis y envejecimiento (oxidacion celular). A diferencia de otros organulos (con excepcion del nucleocelular), la mitocondria presenta su propio genoma; en humanos, este es un ADN circular de 16.600 pares de bases que contiene 37 genes y del que existen multitud de copias distribuidas por toda la mitocondria. La expresion eficiente de estas protenas y acidos es fundamental para su correcto funcionamiento. Por tanto, el mantenimiento de genoma mitocondrial (mtDNA) y replicacion fidedigna son esenciales para la viabilidad celular...
Mitochondria is an essential organelle of the cell. It produces the ATP and plays a fundamental role in process as cell signaling, apoptosis and aging. Although most DNA is packaged in chromosomes within the nucleus, mitochondria has its own DNA, which in humans is a circular genome of 16.600 base pairs that encodes for 37 genes. Human mitochondrial DNA is in a high number of copies distributed through the cell and the correct expression and translation of the proteins and nucleic acids enconded in the DNA is crucial for cell function. Mutations in mtDNA lead to muscular and neurological diseases and are linked to aging, cancer o metabolic disease...
Mitochondria is an essential organelle of the cell. It produces the ATP and plays a fundamental role in process as cell signaling, apoptosis and aging. Although most DNA is packaged in chromosomes within the nucleus, mitochondria has its own DNA, which in humans is a circular genome of 16.600 base pairs that encodes for 37 genes. Human mitochondrial DNA is in a high number of copies distributed through the cell and the correct expression and translation of the proteins and nucleic acids enconded in the DNA is crucial for cell function. Mutations in mtDNA lead to muscular and neurological diseases and are linked to aging, cancer o metabolic disease...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Físicas, Departamento de Estructura de la Materia, Física Térmica y Electrónica, leída el 18-10-2019