Publication: Intervenciones nutricionales en modelos de envejecimiento prematuro y cronológico
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2019-11-28
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Universidad Complutense de Madrid
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Abstract
En el envejecimiento tiene lugar un deterioro funcional progresivo de todos los sistemas fisiológicos del organismo, especialmente de los reguladores, el sistema nervioso, el endocrino y el inmunitario, lo que conlleva la pérdida de homeostasis y el consecuente aumento de morbilidad y mortalidad. Según la teoría de la oxidación-inflamación del envejecimiento, el deterioro al envejecer en los sistemas homeostáticos es consecuencia del estrés oxidativo e inflamatorio crónico del organismo, y en el que el sistema inmunitario está muy implicado. De esta forma, se propone que este sistema que tiene que producir oxidantes e inflamación para llevar a cabo sus funciones,puede, si no está bien regulado, condicionar la velocidad de envejecimiento de cada individuo,siendo un marcador del estado de salud y predictor de longevidad...
Aging is characterized by a progressive deterioration of all physiological systems of the organism, especially those of the regulatory systems namely the nervous, endocrine and immune systems, leading to loss of homeostasis, and consequently increased morbidity and mortality. According to the oxidation-inflammation theory of aging, the age-related deterioration of the regulatory systems is the result of the chronic oxidative and inflammatory stresses. This theory also proposes that the immune system, due to its capacity of producing oxidant and inflammatory compounds in order to carry out its defensive role, if not well regulated, could be involved in the rate of aging. Thus, the immune system has been suggested as a marker of health status and predictor of longevity...
Aging is characterized by a progressive deterioration of all physiological systems of the organism, especially those of the regulatory systems namely the nervous, endocrine and immune systems, leading to loss of homeostasis, and consequently increased morbidity and mortality. According to the oxidation-inflammation theory of aging, the age-related deterioration of the regulatory systems is the result of the chronic oxidative and inflammatory stresses. This theory also proposes that the immune system, due to its capacity of producing oxidant and inflammatory compounds in order to carry out its defensive role, if not well regulated, could be involved in the rate of aging. Thus, the immune system has been suggested as a marker of health status and predictor of longevity...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, leída el 05-09-2019