Publication: The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis
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Publication Date
2019-06
Authors
Wijnker, Erik
Harashima, Hirofumi
Müller, Katja
Parra Núñez, Pablo
Bastiaan de Snoo, C.
Van de Belt, José
Dissmeyer, Nico
Bayer, Martin
Schnittger, Arp
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National Academy of Sciences
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Abstract
Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.