Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

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Escobedo-Ruíz, Araceli and Barquera, Rodrigo and González-Martín, Antonio and Argüelles-San Millán, Juan Manuel and Uribe-Duarte, María Guadalupe and Iraíz Hernández-Zaragoza, Diana and Clayton, Stephen and Arrieta-Bolaños, Esteban and Ruíz Corral, María de Jesús and Goné-Vázquez, Isis and Arellano-Prado, Francia Paulina and Martínez-Álvarez, Julio César and García-Arias, Víctor Eduardo and Rodríguez-López, Marla Estefanía and Bravo-Acevedo, Alicia and Sánchez-Fernández, María Guadalupe de Jesús and Aguilar-Campos, Jesús Abraham and Gómez-Navarro, Benjamín and Sandoval-Sandoval, Mario J. and Serrano-Osuna, Ricardo and Yunis, Edmond J. and Zúñiga, Joaquín and Bekker-Méndez, Carolina and Granados, Julio (2019) Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California. Human immunology . pp. 1-3. ISSN 0198-8859, ESSN: 1879-1166

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Official URL: https://www.sciencedirect.com/science/article/pii/S0198885919305816

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Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes).

Item Type:	Article
Uncontrolled Keywords:	HLA; Immunogenetics; Population genetics; Baja California; Admixture
Subjects:	Medical sciences > Biology > Genetics
ID Code:	58451
Deposited On:	09 Jan 2020 11:19
Last Modified:	11 Jun 2020 23:01

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