Publication: Papel del sistema endocannabinoide en la diferenciación neuronal de células troncales embrionarias y en la reprogramación celular
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2020-01-09
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Universidad Complutense de Madrid
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Abstract
El sistema endocannabinoide (SEC) es un complejo sistema de señalización ampliamente distribuido en el organismo de mamíferos e interviene en multitud de procesos celulares y fisiológicos. Este sistema está formado por los receptores de cannabinoides, sus ligandos endógenos y las enzimas encargadas de la síntesis y degradación de estos. La señalización endocannabinoide participa en multitud de procesos tanto durante el desarrollo embrionario como en el organismo adulto. Su amplia distribución tisular y celular, tanto en el sistema nervioso (SN) como en otros tejidos del organismo, le hace partícipe de numerosos procesos fisiológicos como la proliferación, supervivencia celular y apoptosis, la motilidad y adhesión celular, la transmisión sináptica, el control motor, la memoria, el aprendizaje, la modulación del sistema inmune, el desarrollo neuronal, entre otros procesos,muchos de los cuales aún nos son desconocidos (Skaper & di Marzo, 2012)...
The endocannabinoid system (ECS) is a complex, lipid-based signalling system amply distributed in the organism of mammals that is involved in a variety of cellular and physiological processes. The ECS includes cannabinoid receptors, their endogenous ligands and the enzymes that synthesize and degrade those ligands. Endocannabinoid signalling affects multiple biological functions in the developing and adult organism. Its widespread anatomical localization in the nervous system as well as in other tissues may explain its involvement in an array of physiological roles including cell proliferation, survival and apoptosis, motility and cell adhesion, synaptic transmission, regulation of motor activity, memory and learning, immunomodulation and many others –some of them still unidentified- functions (Skaper & di Marzo, 2012)...
The endocannabinoid system (ECS) is a complex, lipid-based signalling system amply distributed in the organism of mammals that is involved in a variety of cellular and physiological processes. The ECS includes cannabinoid receptors, their endogenous ligands and the enzymes that synthesize and degrade those ligands. Endocannabinoid signalling affects multiple biological functions in the developing and adult organism. Its widespread anatomical localization in the nervous system as well as in other tissues may explain its involvement in an array of physiological roles including cell proliferation, survival and apoptosis, motility and cell adhesion, synaptic transmission, regulation of motor activity, memory and learning, immunomodulation and many others –some of them still unidentified- functions (Skaper & di Marzo, 2012)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Bioquímica y Biología Molecular, leída el 15-11-2019