Publication: Disruptores heterocíclicos de la dimerización de la TryR de "L. infantum" como herramientas terapéuticas innovadoras
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2020-01-16
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Universidad Complutense de Madrid
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Abstract
La leishmaniasis es una enfermedad tropical olvidada considerada como una de las más antiguas de la humanidad, a pesar de que el parásito de Leishmania causante de la patología, no fue descubierto hasta 1901 por William Leishman y Charles Donovan. Dicha especie catalogada como Leishmania donovani, es junto con la Leishmania infantum la responsable de la forma más agresiva de la enfermedad denominada leishmaniasis visceral o kala azar. La leishmaniasis representa tras la malaria, la segunda causa parasitaria de muerte con más de 50.000 defunciones al año. La enfermedad es endémica en más de 97 países. El arsenal de fármacos disponibles para el tratamiento de la leishmaniasis es escaso, obsoleto y presenta problemas de toxicidad y resistencias lo que justifica la urgente necesidad de desarrollar terapias novedosas más eficaces...
Leishmaniasis is a neglected tropical disease considered one of the oldest in humanity, although the Leishmania parasite, which causes the pathology, was not discovered until 1901 by William Leishman and Charles Donovan. This species, classified as Leishmania donovani, is together with Leishmania infantum responsible for the most aggressive form of the disease known as visceral leishmaniasis or kala azar. Leishmaniasis represents, after malaria, the second most deadly parasitic disease causing more than 50,000 deaths per year.The disease is endemic in more than 97 countries. The arsenal of drugs available for the treatment of leishmaniasis is scarce, obsolete and with numerous side effects, toxicity and resistance problems for patients. All this justifies the urgent need to develop novel and more effective therapies...
Leishmaniasis is a neglected tropical disease considered one of the oldest in humanity, although the Leishmania parasite, which causes the pathology, was not discovered until 1901 by William Leishman and Charles Donovan. This species, classified as Leishmania donovani, is together with Leishmania infantum responsible for the most aggressive form of the disease known as visceral leishmaniasis or kala azar. Leishmaniasis represents, after malaria, the second most deadly parasitic disease causing more than 50,000 deaths per year.The disease is endemic in more than 97 countries. The arsenal of drugs available for the treatment of leishmaniasis is scarce, obsolete and with numerous side effects, toxicity and resistance problems for patients. All this justifies the urgent need to develop novel and more effective therapies...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 18-10-2019