Publication: Efectos del ácido hialurónico en la extracción quirúrgica del tercer molar inferior: estudio clínico aleatorio controlado con placebo
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2020-01-21
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Universidad Complutense de Madrid
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Abstract
Se realizan grandes esfuerzos para controlar la triada habitual de efectos secundarios postoperatorios que sufren los pacientes tras la cirugía del tercer molar inferior, perjudicando su calidad de vida. Entre los más estudiados estarían los antiinflamatorios no esteroideos, los corticoides, los antibióticos, los antisépticos y sustancias naturales. El ácido hialurónico es un polisacárido de alto peso molecular, aislado inicialmente por Meyer y Palmer en 1934, está presente en multitud de fluidos y tejidos del organismo y se le atribuyen características tales como : efecto cicatrizante, poder antibacteriano, antifúngico, hidratante, antiinflamatorio y analgésico, entre otras. Es altamente biocompatible y se reportan nulos o leves efectos secundarios, si bien en cirugía bucal existen pocas publicaiones sobre su aplicación. OBJETIVOS: Comparar clínicamente el efecto de la aplicación local del gel de ácido hialurónico al 0,6% frente a un placebo en las heridas quirúrgicas de la cirugía del tercer molar mandibular valorando sus efectos sobre el dolor, trismo e inflamación típicos de esta intervención. valorar la aparición de efectos adversoso o complicaciones en los pacientes asociados al tratamiento.
Big efforts are made to control the postoperative side effects suffered by patients after the surgery of the lower third molar. the more studied side effects are: anti-inflammatory drugs, corticosteroids, antibiotics, antiseptic and natural substances. Hyaluronic Acid is a high molecular weight polysaccharide isolated by Meyer and Palmer in 1934. It is a component of many fluids and tissues in the human body and has multiple characteristics, such as: healing effect, antifungal, analgesic and anti-inflammatory propieties. It is highly biocompatible and it has reported none or few side effects. there are few articles about its use in oral surgery. OBJECTIVES: Compare the effects produced between the local application of the hyaluronic gel at 0,6% and a placebo on surgical wounds evaluating pain, trismus and inflammation which are typical of this procedure. Assess the emergence of adverse effects or complications in patients associated with the treatment.
Big efforts are made to control the postoperative side effects suffered by patients after the surgery of the lower third molar. the more studied side effects are: anti-inflammatory drugs, corticosteroids, antibiotics, antiseptic and natural substances. Hyaluronic Acid is a high molecular weight polysaccharide isolated by Meyer and Palmer in 1934. It is a component of many fluids and tissues in the human body and has multiple characteristics, such as: healing effect, antifungal, analgesic and anti-inflammatory propieties. It is highly biocompatible and it has reported none or few side effects. there are few articles about its use in oral surgery. OBJECTIVES: Compare the effects produced between the local application of the hyaluronic gel at 0,6% and a placebo on surgical wounds evaluating pain, trismus and inflammation which are typical of this procedure. Assess the emergence of adverse effects or complications in patients associated with the treatment.
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Odontología, Departamento de Especialidades Clínicas Odontológicas l, leída el 06-11-2019