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Arcos Navarrete, Daniel and Vallet Regí, María (2020) Substituted hydroxyapatite coatings of bone implants. Journal of Materials Chemistry B . ISSN 2050-750X
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Official URL: https://www.rsc.org/journals-books-databases/about-journals/journal-of-materials-chemistry-b/
Abstract
Surface modification of orthopedic and dental implants has been demonstrated to be an effective strategy to accelerate bone healing at early implantation times. Among the different alternatives, coating implants with a layer of hydroxyapatite (HAp) is one of the most used techniques, due to its excellent biocompatibility and osteoconductive behavior. The composition and crystalline structure of HAp allow for numerous ionic substitutions that provide added value, such as antibiotic properties or osteoinduction. In this article, we will review and critically analyze the most important advances in the field of substituted hydroxyapatite coatings. In recent years substituted HAp coatings have been deposited not only on orthopedic prostheses and dental implants, but also on macroporous scaffolds, thus expanding their applications towards bone regeneration therapies. Besides, the capability of Q4 substituted HAps to immobilize proteins and growth factors by non-covalent interactions has opened new possibilities for preparing hybrid coatings that foster bone healing processes. Finally, the most important in vivo outcomes will be discussed to understand the perspectives of substituted HAp Q5 coatings from a clinical point of view.
Item Type: | Article |
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Additional Information: | RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete) |
Subjects: | Sciences > Chemistry > Materials Medical sciences > Pharmacy > Inorganic chemistry |
ID Code: | 59096 |
Deposited On: | 02 Mar 2020 11:11 |
Last Modified: | 18 Feb 2021 23:00 |
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