Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery



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Gisbert Garzarán, Miguel and Berkmann, Julia and Giasafaki, Dimitra and Lozano Borregón, Daniel and Spyrou, Konstantinos and Manzano García, Miguel and Steriotis, Theodore A and Duda, Georg and Schmidt-Bleek, Katharina and Charalambopoulou, Georgia and Vallet Regí, María (2020) Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery. ACS Applied Materials & Interfaces . ISSN 1944-8244 (In Press)

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In this work, two types of mesoporous carbon particles with different morphology, size and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their textural properties allow significantly higher loading capacity compared to typical mesoporous silica nanoparticles. In vial release experiments of a model Ru dye at pH 7.4 and 5 confirm the pH-responsiveness of the hybrid systems, showing that only small amounts of the cargo are released at physiological pH, whereas at slightly acidic pH (e.g. that of lysosomes) self-immolation takes place and a significant amount of the cargo is released.
Cytotoxicity studies using human osteosarcoma cells show that the hybrid nanocarriers are not cytotoxic by themselves but induce significant cell growth inhibition when loaded with a chemotherapeutic drug such as doxorubicin. In preparation of an in vivo application, in vial responsiveness of the hybrid system to short-term pH-triggering is confirmed. The consecutive in vivo study shows no substantial cargo release over a period of 96 hours under physiological pH conditions. Short-term exposure to acidic pH releases an experimental fluorescent cargo during and continuously after the triggering period over 72 hours.

Item Type:Article
Additional Information:

RESEARCHER ID BS-2443-2016 (Miguel Gisbert Garzarán)
ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous Carbons, pH-responsive, self-immolative coating, drug delivery, controlled release
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:59454
Deposited On:20 Mar 2020 09:43
Last Modified:07 Mar 2021 23:00

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