Publication: Perfil de aminoácidos plasmáticos y expresión génica de receptores de neurotransmisores tras la autoadministración de cocaína y alcohol en ratas
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2020-03-31
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Universidad Complutense de Madrid
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Abstract
A pesar de la aparición constante de nuevas drogas de abuso y de los cambios en sus patrones de consumo, el uso simultáneo de cocaína (un éster de ácido benzoico y metilecgonina) y el alcohol (alcohol etílico) continúa siendo muy frecuente en países occidentales como España. La alta prevalencia de alcoholismo o el consumo excesivo de alcohol entre los consumidores de cocaína puede deberse a un intento de mitigar algunos síntomas negativos de la cocaína, como la ansiedad, y/o de aumentar otros efectos positivos e, incluso, deseados como la euforia o una mejor percepción del bienestar físico. Al igual que otras formas de policonsumo, el uso conjunto de cocaína y alcohol comienza frecuentemente durante el período de transición desde la adolescencia a la edad adulta y se asocia con importantes consecuencias para la salud...
Despite the constant appearance of new drugs of abuse and new consumption patterns, the combined use of cocaine and ethyl alcohol is a prevalent practice in Western countries, included Spain. In the present study, the polydrug use has been addressed by using an animal model of intravenous administration. Our work has been developed in three phases. In a first phase (Study I) a series of experiments were carried out with adult male Wistar rats, which received passively and intravenously: cocaine (1mg/kg body weight/injection); alcohol (133 mg/kg body weight/injection); cocaine plus alcohol (1 mg/kg body weight/injection + 133 mg/kg body weight/injection); and saline (0,9 % NaCl). After 21 days of this administration regimen, plasma levels of nine amino acids were quantified by capillary electrophoresis with laser-induced fluorescence detection (capillary-LIF electrophoresis)...
Despite the constant appearance of new drugs of abuse and new consumption patterns, the combined use of cocaine and ethyl alcohol is a prevalent practice in Western countries, included Spain. In the present study, the polydrug use has been addressed by using an animal model of intravenous administration. Our work has been developed in three phases. In a first phase (Study I) a series of experiments were carried out with adult male Wistar rats, which received passively and intravenously: cocaine (1mg/kg body weight/injection); alcohol (133 mg/kg body weight/injection); cocaine plus alcohol (1 mg/kg body weight/injection + 133 mg/kg body weight/injection); and saline (0,9 % NaCl). After 21 days of this administration regimen, plasma levels of nine amino acids were quantified by capillary electrophoresis with laser-induced fluorescence detection (capillary-LIF electrophoresis)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Farmacología y Toxicología, leída el 28-11-2019