Publication: Identificación de las proteínas fosfatasas responsables de la inactivación de las MAP quinasas en neuronas granulares de cerebelo:papel de los receptores P2X7 y Trks
Loading...
Files
Official URL
Full text at PDC
Publication Date
2020-03-31
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
La neurotransmisión purinérgica en el cerebelo ha sido ampliamente estudiada por nuestro grupo de investigación, habiéndose caracterizado en trabajos previos las rutas de señalización activadas por los receptores de nucleótidos en neuronas granulares y astrocitos cerebelosos (Espada et al., 2010; Carrasquero et al., 2009; Ortega et al., 2010; Ortega et al., 2011). En las neuronas granulares, los receptores ionotrópicos P2X7 y los receptores metabotrópicos P2Y13 ejercen efectos neuroprotectores frente a diferentes estímulos proapoptóticos, activando diversas cascadas de señalización. Entre ellas se encuentra la ruta de supervivencia que conduce a la inhibición de GSK3 (Glucógeno Sintasa Quinasa 3), bien a través de la vía canónica PI3K/Akt (Fosfatidilinositol-3-Quinasa/ Proteína Quinasa B) para el receptor P2Y13, como a través de una vía dependiente de la PKC (Proteína Quinasa C) para el receptor P2X7. Ambos receptores también activan las proteínas MAP quinasas, ERK1,2 (Quinasa regulada por señalización extracelular), señalizando a través de la CaMKII (Calcio Calmodulina Quinasa II ) en el caso de P2X7, y de la vía PI3K/Akt para el receptor P2Y13 (Ortega et al., 2008; Ortega et al., 2009; Ortega et al., 2011)...
Purinergic neurotransmission in the cerebellum has been widely studied by our research group, being identified several signaling pathways activated by nucleotide receptors in cerebellar granule neurons and astrocytes (Espada et al., 2010; Carrasquero et al., 2009; Ortega et al., 2010; Ortega et al., 2011). In granule neurons, P2X7 ionotropic receptor and P2Y13 metabotropic receptor exert neuroprotective effects against several proapoptotic stimuli, activating different signalling pathways. These include the survival pathway leading to GSK3 (Glycogen synthase kinase 3) inhibition, either through the PI3K/Akt (Phosphoinositide 3-kinase/ Protein kinase B) canonical pathway for P2Y13 receptor, or through a protein kinase C-dependent pathway for the P2X7 receptor. In addition, both receptors activate the MAP Kinases, ERK1,2 (Extracellular signal–regulated kinases), through CaMKII (Calcium calmodulin kinase II) and PI3K/Akt for P2X7 and P2Y13 receptors, respectively (Ortega et al., 2008; Ortega et al., 2009; Ortega et al., 2011)...
Purinergic neurotransmission in the cerebellum has been widely studied by our research group, being identified several signaling pathways activated by nucleotide receptors in cerebellar granule neurons and astrocytes (Espada et al., 2010; Carrasquero et al., 2009; Ortega et al., 2010; Ortega et al., 2011). In granule neurons, P2X7 ionotropic receptor and P2Y13 metabotropic receptor exert neuroprotective effects against several proapoptotic stimuli, activating different signalling pathways. These include the survival pathway leading to GSK3 (Glycogen synthase kinase 3) inhibition, either through the PI3K/Akt (Phosphoinositide 3-kinase/ Protein kinase B) canonical pathway for P2Y13 receptor, or through a protein kinase C-dependent pathway for the P2X7 receptor. In addition, both receptors activate the MAP Kinases, ERK1,2 (Extracellular signal–regulated kinases), through CaMKII (Calcium calmodulin kinase II) and PI3K/Akt for P2X7 and P2Y13 receptors, respectively (Ortega et al., 2008; Ortega et al., 2009; Ortega et al., 2011)...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Bioquímica y Biología Molecular, leída el 08-11-2019