H2-Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration

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Gutiérrez-Sanz, Óscar and Natale, Paolo and Márquez, Ileana and Marques, Marta C. and Zacarias, Sonia and Pita, Marcos and Pereira, Inês A. C. and López-Montero, Iván and De Lacey, Antonio L. and Vélez, Marisela (2016) H2-Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration. Angewandte Chemie International Edition, 55 (21). pp. 6216-6220. ISSN 1433-7851

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Official URL: https://doi.org/10.1002/anie.201600752



Abstract

ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a F1F0 -ATPase in a lipid membrane can couple the electrochemical oxidation of H2 to the synthesis of ATP. This electrode-assisted conversion of H2 gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable product.


Item Type:Article
Additional Information:

The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n° 338133)

Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Physical and theoretical
ID Code:60106
Deposited On:23 Apr 2020 07:23
Last Modified:23 Apr 2020 07:23

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