Nanocomposite Hydrogels as Platform for Cells Growth, Proliferation, and Chemotaxis

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Fiorini, Federica and Prasetyanto, Eko Adi and Taraballi, Francesca and Pandolfi, Laura and Monroy Muñoz, Francisco and López-Montero, Iván and Tasciotti, Ennio and De Cola, Luisa (2016) Nanocomposite Hydrogels as Platform for Cells Growth, Proliferation, and Chemotaxis. Small, 12 (35). pp. 4881-4893. ISSN 1613-6810

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Official URL: https://doi.org/10.1002/smll.201601017



Abstract

The challenge of mimicking the extracellular matrix with artificial scaffolds that are able to reduce immunoresponse is still unmet. Recent findings have shown that mesenchymal stem cells (MSC) infiltrating into the implanted scaffold have effects on the implant integration by improving the healing process. Toward this aim, a novel polyamidoamine-based nanocomposite hydrogel is synthesized, crosslinked with porous nanomaterials (i.e., mesoporous silica nanoparticles), able to release chemokine proteins. A comprehensive viscoelasticity study confirms that the hydrogel provides optimal structural support for MSC infiltration and proliferation. The efficiency of this hydrogel, containing the chemoattractant stromal cell-derived factor 1α (SDF-1α), in promoting MSC migration in vitro is demonstrated. Finally, subcutaneous implantation of SDF-1α-releasing hydrogels in mice results in a modulation of the inflammatory reaction. Overall, the proposed SDF-1α-nanocomposite hydrogel proves to have potential for applications in tissue engineering.


Item Type:Article
Additional Information:

The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n° 338133)

Uncontrolled Keywords:Chemotaxis; Hydrogel; In vivo implant; Mesoporous particles; Nanocomposites
Subjects:Sciences > Chemistry > Materials
ID Code:60107
Deposited On:22 Apr 2020 15:37
Last Modified:22 Apr 2020 15:37

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