The enzymatic sphingomyelin to ceramide conversion increases the shear membrane viscosity at the air-water interface

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Catapano, Elisa R. and Natale, Paolo and Monroy Muñoz, Francisco and López-Montero, Iván (2017) The enzymatic sphingomyelin to ceramide conversion increases the shear membrane viscosity at the air-water interface. Advances in Colloid and Interface Science, 247 . pp. 555-560. ISSN 0001-8686

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Official URL: https://doi.org/10.1016/j.cis.2017.07.014



Abstract

Whereas most of lipids have viscous properties and they do not have significant elastic features, ceramides behave as very rigid solid assemblies, displaying viscoelastic behaviour at physiological temperatures. The present review addresses the surface rheology of lipid binary mixtures made of sphingomyelin and ceramide. However, ceramide is formed by the enzymatic cleavage of sphingomyelin in cell plasma membranes. The consequences of the enzymatically-driven ceramide formation involve mechanical alterations of the embedding membrane. Here, an increase on surface shear viscosity was evidenced upon enzymatic incubation of sphingomyelin monolayers. The overall rheological data are discussed in terms of the current knowledge of the thermotropic behaviour of ceramide-containing model membranes.


Item Type:Article
Additional Information:

The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n° 338133)

Uncontrolled Keywords:Sphingomyelinase; Shear rheology; Langmuir monolayers; Ceramides; Sphingolipids
Subjects:Sciences > Chemistry > Chemistry, Physical and theoretical
ID Code:60117
Deposited On:23 Apr 2020 07:28
Last Modified:23 Apr 2020 07:28

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