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Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles.

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Gisbert Garzarán, Miguel and Vallet Regí, María (2020) Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles. Nanomaterials, 10 . p. 916. ISSN 2079-4991

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Official URL: https://www.mdpi.com/journal/nanomaterials




Abstract

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems 14 owing to their exquisite features, such as excellent textural properties or biocompatibility. However, 15 there are various biological barriers that prevent their proper translation into the clinic, including 16 (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal 17 sequestration of the particles upon internalization.
In addition, their open porous structure may 18 lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy 19 of the treatment. First, this review will provide a comprehensive and systematic overview of the 20 different approximations that have been implemented into mesoporous silica nanoparticles to 21 overcome each of such biological barriers. Afterward, the potential premature and non-specific drug 22 release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli23 responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.


Item Type:Article
Additional Information:

RESEARCHER ID S-2443-2016 (Miguel Gisbert Garzarán)
ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous silica nanoparticles, Cancer, Drug delivery, Targeting, Biological barriers, Endosomal escape, Stimuli-responsive, Controlled drug release, Nanomedicine.
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:60445
Deposited On:02 Jun 2020 10:06
Last Modified:02 Jun 2020 16:04

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