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Torres, Sandra and Abdullah, Zeinab and Brol, Maximilian J. and Hellerbrand, Claus and Fernández, Mercedes and Fiorotto, Romina and Klein, Sabine and Königshofer, Philipp and Liedtke, Christian and Lotersztajn, Sophie and Nevzorova, Yulia A. and Schierwagen, Robert and Reiberger, Thomas and Uschner, Frank Erhard and Tacke, Frank and Weiskirchen, Ralf and Trebicka, Jonel (2020) Recent advances in practical methods for liver cell biology: a short overview. International Journal of Molecular Sciences, 21 (6). pp. 1-19. ISSN 1661-6596, ESSN: 1422-0067
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Official URL: https://www.mdpi.com/1422-0067/21/6/2027
Abstract
Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.
Item Type: | Article |
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Uncontrolled Keywords: | Hepatic stellate cells; Hepatocellular cancer; Fibrogenesis; Steatosis; In vitro models |
Subjects: | Medical sciences > Medicine > Gastroenterology and Hepatology Medical sciences > Biology > Cytology Medical sciences > Biology > Molecular biology |
ID Code: | 60724 |
Deposited On: | 02 Jun 2020 08:31 |
Last Modified: | 15 Sep 2020 09:28 |
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