Thymus Ontogeny and Development

Downloads

Downloads per month over past year

61145

Impacto

Downloads

Downloads per month over past year

Muñoz, J.J. and Zapata González, Agustín Gregorio (2019) Thymus Ontogeny and Development. In Thymus Transcriptome and Cell Biology. Springer, Switzerland, pp. 19-34. ISBN 978-3-030-12040-5

[thumbnail of Zapata-DBC-Thymus-ontogeny.pdf] PDF
Restringido a Repository staff only

680kB

Official URL: https://link.springer.com/chapter/10.1007%2F978-3-030-12040-5_2



Abstract

The thymus is a primary lymphoid organ constituted by a 3D epithelial network that provides a specialized microenvironment in which seeding lymphoid progenitors undergo phenotypical and functional maturation. During the earlier steps of thymic organogenesis, the specification of the pharyngeal endoderm to thymus fate takes place independently of the expression of the transcription factor Foxn1 that, however, governs the later organogenesis of thymus together with the colonizing lymphoid cells. In the present chapter, we will review evidence describing early development of thymus and its resemblance with the development of endoderm-derived epithelial organs based on tubulogenesis and branching morphogenesis as well as the molecules known to be involved in these processes.

Resumen (otros idiomas)

Este capítulo de libro revisa los procesos de especificación del epitelio tímico inducidos por Foxn1 en el endodermo común de la tercera bolsa faríngea, el fenómeno de la tubulogénesis y el branching de dicho primordio y las moléculas implicadas en tales procesos así como el papel de los progenitores linfoides que colonizan el primordio tímico durante el desarrollo

Item Type:Book Section
Subjects:Medical sciences > Biology > Cytology
ID Code:61145
Deposited On:26 Jun 2020 16:07
Last Modified:26 Jun 2020 16:07

Origin of downloads

Repository Staff Only: item control page