Animal models for liver disease – A practical approach for translational research

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Nevzorova, Yulia A. and Boyer-Diaz, Zoe and Cubero, Francisco Javier and Gracia Sancho, Jordi (2020) Animal models for liver disease – A practical approach for translational research. Journal of Hepatology . pp. 1-18. ISSN 0168-8278, ESSN: 1600-0641 (In Press)

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Official URL: https://www.sciencedirect.com/science/article/pii/S0168827820302233



Abstract

Animal models are crucial for improving our understanding of human pathogenesis, enabling researchers to identify therapeutic targets and test novel drugs. In the current review, we provide a comprehensive summary of the most widely used experimental models of chronic liver disease, starting from early stages of fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, advanced cirrhosis and end-stage primary liver cancer. We focus on aspects such as reproducibility and practicality, discussing the advantages and weaknesses of available models for researchers who are planning to perform animal studies in the near future. Additionally, we summarise current and prospective models based on human tissue bioengineering.


Item Type:Article
Uncontrolled Keywords:Non-alcoholic fatty liver disease; NAFLD; Nonalcoholic steatohepatitis; NASH; ALD; Fibrosis; Cirrhosis; Primary liver cancer
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
ID Code:61391
Deposited On:07 Jul 2020 14:21
Last Modified:21 Apr 2021 22:00

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