A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Diseases



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Martínez, Carmen and Juarranz Moratilla, Yasmina and Gutiérrez Cañas, Irene and Carrión Caballo, Mar and Pérez García, Selene and Villanueva Romero, Raúl and Castro Moreno, David and Lamana, Amalia and Mellado, Mario and González Álvaro, Isidoro and Gomáriz, Rosa P. (2019) A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Diseases. International Journal of Molecular Sciences, 21 (1). p. 65. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms21010065


The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenous neuropeptide produced by neurons and endocrine and immune cells, involved in the control of both innate and adaptive immune responses. Exogenous administration of VIP exerts therapeutic effects in models of autoimmune/inflammatory diseases mediated by G-protein-coupled receptors (VPAC1 and VPAC2). Currently, there are no curative therapies for inflammatory and autoimmune diseases, and patients present complex diagnostic, therapeutic, and prognostic problems in daily clinical practice due to their heterogeneous nature. This review focuses on the biology of VIP and VIP receptor signaling, as well as its protective effects as an immunomodulatory factor. Recent progress in improving the stability, selectivity, and effectiveness of VIP/receptors analogues and new routes of administration are highlighted, as well as important advances in their use as biomarkers, contributing to their potential application in precision medicine. On the 50th anniversary of VIP’s discovery, this review presents a spectrum of potential clinical benefits applied to inflammatory and autoimmune diseases.

Item Type:Article
Uncontrolled Keywords:Vasoactive intestinal peptide; VPAC1 receptor; VPAC2 receptor; Rheumatic diseases; Inflammatory bowel disease; Central nervous system diseases; Type 1 diabetes, Sjögren’s syndrome; Biomarkers
Subjects:Medical sciences > Biology > Cytology
ID Code:61601
Deposited On:21 Jul 2020 16:42
Last Modified:21 Jul 2022 11:04

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