Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin

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Pérez García, Selene and Carrión Caballo, Mar and Gutiérrez-Cañas, Irene and Villanueva-Romero, Raúl and Castro Moreno, David and Martínez, Carmen and González-Álvaro, Isidoro and Blanco, Francisco J. and Juarranz Moratilla, Yasmina and Gomáriz, Rosa P. (2019) Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin. Cells, 9 (1). p. 40. ISSN 2073-4409

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Official URL: https://doi.org/10.3390/cells9010040



Abstract

The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs.


Item Type:Article
Uncontrolled Keywords:Osteoarthritis, fibronectin, proteinases, uPA, MMP, ADAMTS
Subjects:Medical sciences > Medicine > Rheumatology
Medical sciences > Biology > Cytology
ID Code:61619
Deposited On:22 Jul 2020 17:16
Last Modified:08 Sep 2020 10:11

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